2-(3,4-dichlorobenzyl)-N-(2-hydroxyethyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide | 1189526-81-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(3,4-dichlorobenzyl)-N-(2-hydroxyethyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide
• 英文别名: 2-[(3,4-dichlorophenyl)methyl]-N-(2-hydroxyethyl)-3-oxo-[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide
• CAS: 1189526-81-5
• 化学式: C₁₆H₁₄Cl₂N₄O₃
• 分子量: 381.218
• InChiKey: JSCHCUAUVSTTPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• TRIAZOLOPYRIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
  申请人：Koltun Dmitry

  公开号：US20090253738A1

  公开（公告）日：2009-10-08

  The present invention discloses triazolopyridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.

  本发明揭示了三唑并吡啶酮衍生物，用作硬脂酰辅酶A去饱和酶的抑制剂，其结构为式I：这些化合物可用于治疗和/或预防由硬脂酰辅酶A去饱和酶（SCD）酶介导的各种人类疾病，特别是与异常脂质水平、心血管疾病、糖尿病、肥胖症、代谢综合征等有关的疾病。
• TRIAZOLOPYRIDINONE DERIVATIVES FOR USE AS STEAROYL COA DESATURASE INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：EP2268637A1

  公开（公告）日：2011-01-05
• US8088792B2
  申请人：——

  公开号：US8088792B2

  公开（公告）日：2012-01-03
• [EN] TRIAZOLOPYRIDINONE DERIVATIVES FOR USE AS STEAROYL COA DESATURASE INHIBITORS<br/>[FR] DÉRIVÉS DE TRIAZOLOPYRIDINONE DESTINÉS À ÊTRE UTILISÉS COMME INHIBITEURS DE LA STÉAROYL-COA DÉSATURASE
  申请人：CV THERAPEUTICS INC

  公开号：WO2009137201A1

  公开（公告）日：2009-11-12

  The present invention discloses triazolopyridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.