(Z)-2-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)methylene-4H-9,10-dihydrobenzo[4,5]cyclohepta[1,2-b]thiophene | 1207546-04-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (Z)-2-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)methylene-4H-9,10-dihydrobenzo[4,5]cyclohepta[1,2-b]thiophene
• 英文别名: 3-[(Z)-[5-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-2-ylidene]methyl]-4H-1,2,4-oxadiazol-5-one
• CAS: 1207546-04-0
• 化学式: C₂₇H₂₅N₅O₂S
• 分子量: 483.594
• InChiKey: ODUMVLOFOJXAMN-MOSHPQCFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• TRICYCLIC COMPOUND
  申请人：Yanagisawa Arata

  公开号：US20110201640A1

  公开（公告）日：2011-08-18

  Provided is a tricyclic compound having a PPAR γ agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R 4 -R 9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R 10 and R 11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:

  提供了一种三环化合物，具有PPARγ激动剂活性，其通式表示为（I），其中Z代表单键或类似物，Y代表氢原子，可选具有取代基的低碳基或类似物，X代表氢原子或类似物，A代表芳基或类似物，B和C相同或不同，每个代表芳香烃环或类似物，R4-R9相同或不同，每个代表氢原子或类似物，V代表单键或类似物，R10和R11相同或不同，每个代表氢原子或类似物，或其药学上可接受的盐或类似物。
• US8486980B2
  申请人：——

  公开号：US8486980B2

  公开（公告）日：2013-07-16
• US9475805B2
  申请人：——

  公开号：US9475805B2

  公开（公告）日：2016-10-25