Tetrahydro-2H-pyrazino[1,2-A]pyrimidine-4,7(3H,6H)-dione | 348112-92-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: Tetrahydro-2H-pyrazino[1,2-A]pyrimidine-4,7(3H,6H)-dione
• 英文别名: 2,3,6,8,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrimidine-4,7-dione
• CAS: 348112-92-5
• 化学式: C₇H₁₁N₃O₂
• 分子量: 169.18
• InChiKey: CYCRMTFRHLQFIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  61.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• HEXAHYDRO-PYRAZINO[1,2-A]PYRIMIDINE-4,7-DIONE DERIVATIVES SUBSTITUTED WITH AMINO ACIDS
  申请人：Lennig Petra

  公开号：US20070197539A1

  公开（公告）日：2007-08-23

  The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives substituted with amino acids, and to the physiologically tolerated salts thereof, processes for their preparation and their use as medicaments

  该发明涉及用氨基酸取代的六氢吡嗪[1,2-a]嘧啶-4,7-二酮衍生物，以及其生理耐受盐，其制备方法以及作为药物的用途。
• [DE] MIT AMINOSÄUREN SUBSTITUIERTE HEXAHYDRO-PYRAZINO[1,2-A]PYRIMIDIN-4, 7-DIONDERIVATE<br/>[EN] HEXAHYDRO-PYRAZINO[1,2-A]PYRIMIDINE-4, 7-DIONE DERIVATIVES SUBSTITUTED WITH AMINO ACIDS<br/>[FR] DERIVES D'HEXAHYDRO-PYRAZINO[1,2-A]PYRIMIDIN-4,7-DIONE SUBSTITUES PAR DES AMINOACIDES, LEUR PROCEDE DE PRODUCTION, ET LEUR UTILISATION EN TANT QUE MEDICAMENTS
  申请人：SANOFI AVENTIS DEUTSCHLAND

  公开号：WO2006024390A1

  公开（公告）日：2006-03-09

  Die Erfindung betrifft substituierte Hexahydro-pyrazino[1,2-a]pyrimidin-4,7-dionderivate sowie deren physiologisch verträgliche Salze und physiologisch funktionelle Derivate. Es werden Verbindungen der Formel (I), worin die Reste die angegebenen Bedeutungen haben, sowie deren physiologisch verträglichen Salze und Verfahren zu deren Herstellung beschrieben. Die Verbindungen eignen sich z.B. als Anorektika.

  这项发明涉及取代的六氢吡嗪[1,2-a]嘧啶-4,7-二酮衍生物，以及其生理相容性盐和生理功能衍生物。描述了具有以下结构的化合物（I），其中残基具有所示含义，以及其生理相容性盐和制备方法。这些化合物可用作食欲抑制剂。
• Substituted hexahydropyrazino (1,2-a) pyrimidine-4,7-dione derivatives, processes for their preparation and their use as medicaments
  申请人：Flohr Stefanie

  公开号：US20050004131A1

  公开（公告）日：2005-01-06

  Substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, processes for their preparation and their use as medicaments The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example as anorectic agents.

  取代的六氢吡嗪[1,2-a]嘧啶-4,7-二酮衍生物，其制备方法及其用作药物。本发明涉及取代的六氢吡嗪[1,2-a]嘧啶-4,7-二酮衍生物以及其生理耐受盐和生理功能衍生物。描述了具有以下式I的化合物，其中基团具有所述含义，以及其生理耐受盐和制备它们的方法。这些化合物例如适用于作为厌食剂。
• Nitrogen-substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, processes for their preparation and their use as medicaments
  申请人：Flohr Stefanie

  公开号：US20050085483A1

  公开（公告）日：2005-04-21

  Nitrogen-substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, processes for the preparation and their use as medicaments The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example as anorectic agents.

  氮取代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物及其制备方法和作为药物的用途。本发明涉及取代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物及其生理耐受盐和生理功能衍生物，其中基团具有所述含义，并描述了其生理耐受盐及其制备方法。该化合物适用于例如作为厌食剂。
• SUBSTITUTED HEXAHYDROPYRAZINO [1,2-A] PYRIMIDINE-4,7-DIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：Flohr Stefanie

  公开号：US20080221113A1

  公开（公告）日：2008-09-11

  Substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, processes for their preparation and their use as medicaments The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example as anorectic agents.

  替代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物，其制备过程以及作为药物的用途。本发明涉及替代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物及其生理上可耐受的盐和生理上功能性衍生物。描述了式I的化合物，其中基团具有所述的含义，以及其生理上可耐受的盐和制备它们的方法。这些化合物例如适用于作为抑制食欲的药物。