1,10-bis(triethylphosphonium)decane dibromide | 114302-97-5

• 分子结构分类: 有机化合物 - 有机磷化合物 - 四烷基鏻化合物
• 英文名称: 1,10-bis(triethylphosphonium)decane dibromide
• 英文别名: hexa-P-ethyl-P,P'-decanediyl-di-phosphonium; dibromide；Hexa-P-aethyl-P,P'-decandiyl-di-phosphonium; Dibromid
• CAS: 114302-97-5
• 化学式: 2Br*C₂₂H₅₀P₂
• 分子量: 536.395
• InChiKey: ZPFUKTLQBVVLDF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  5.27
• 重原子数：
  25.0
• 可旋转键数：
  17.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为产物：
  描述：

  1,10-二溴癸烷 、 三乙基膦 以 四氢呋喃 为溶剂， 反应 72.0h， 以2%的产率得到1,10-bis(triethylphosphonium)decane dibromide
  参考文献：
  名称：

  Host−Guest Complexes and Pseudorotaxanes of Cucurbit[7]uril with Acetylcholinesterase Inhibitors

  摘要：

  Pseudorotaxanes may be assembled in aqueous solution using dicationic acetylcholinesterase inhibitors, such as succinylcholine, BW284c51, and alpha,omega-bis(trialkylammonium)alkane dications (or their phosphonium analogues), its bolaform axles and cucurbit[7]uril (CB[7]) as the wheel. With the exceptions of the shorter [(CH3)(3)N(CH2)(n)N(CH3)(3)](2+) (n = 6, 8) dications, the addition of it second CB[7] results in the translocation of the First CB[7], Such that the hydrophobic -NR3+ and -PR3+ end groups (R = Me or Et) are located in the cavities of the wheels, while the central portion of the axles extend through the CB[7] portals into the bulk solvent. In the case of the [Quin(CH2)(10)Quin](2+) (Quin = quinuclidinium) dication, the CB[7] host(s) resides only on the quinuclidinium end group(s). The 1.1 host-guest stability constants range from 8 x 10(6) to 3 x 10(10) M-1 and are dependent oil both the nature of the end group as well its the length and hydrophobicity of the central linker. The magnitude of the stability constants for the 2.1 complexes closely follow the trend observed previously for CB[7] binding with the NR4+ and PR4+ cations.

  DOI：

  10.1021/jo901861e

文献信息

• Alkylenebis [trialkylphosphonium halides] and processes for the manufacture thereof
  申请人：SEARLE &

  公开号：US02867665A1

  公开（公告）日：1959-01-06