3-ethyl-pyrazole-1-carboxylic acid amide | 40014-38-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-ethyl-pyrazole-1-carboxylic acid amide
• 英文别名: 3-ethyl-1H-pyrazole-1-carboxamide；3-ethylpyrazole-1-carboxamide
• CAS: 40014-38-8
• 化学式: C₆H₉N₃O
• mdl: MFCD18809506
• 分子量: 139.157
• InChiKey: RMCLBUDNFMGZAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  60.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1458379A1

  公开（公告）日：2004-09-22
• [EN] HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM<br/>[FR] DERIVES D'HYDROXYPHENYL-PYRAZOLE SERVANT D'INHIBITEURS DE KINASE, PROCEDE POUR LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2003051358A1

  公开（公告）日：2003-06-26

  The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof and effective amount of o-hydroxy phenyl-pyrazol-3-yl derivatives optionally substituted of formula (I). The invention also provides some new compounds, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.