3-溴-N-苯乙基苯甲酰胺 | 328931-57-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-溴-N-苯乙基苯甲酰胺
• 英文名称: 3-bromo-N-phenethyl benzamide
• 英文别名: N-phenethyl-3-bromobenzamide；3-bromo-N-phenethylbenzamide；3-bromo-N-(2-phenylethyl)benzamide
• CAS: 328931-57-3
• 化学式: C₁₅H₁₄BrNO
• mdl: MFCD00554086
• 分子量: 304.186
• InChiKey: HMWLHGJHPSGMEB-UHFFFAOYSA-N

物化性质

• 沸点：
  449.3±38.0 °C(Predicted)
• 密度：
  1.362±0.06 g/cm3(Predicted)
• 溶解度：
  10 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-溴-N-苯乙基苯甲酰胺 在 四磷十氧化物 、 三氯氧磷 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 生成 1-(3-溴苯基)-3,4-二氢异喹啉
  参考文献：
  名称：

  Bipolar iridium dendrimers containing carbazolyl dendron and 1,2,4-triazole unit for solution-processed saturated red electrophosphorescence

  摘要：

  Two solution-processable, carbazole-based iridium dendrimers (Ir-1 and Ir-2) were synthesized and characterized. The presence of carbazolyl substituent on the cyclometallated ligand resulted in improved solubility, good control over intermolecular interactions, and improved hole transport properties. The triazole ancillary ligand led to improved electron transport properties. When the dendrimers were employed as host-free light-emitting layers in the OLEDs, the devices exhibited a low turn-on voltage of 5.4 V. The maximal external quantum efficiencies and luminous efficiency of the devices obtained from Ir-1 and Ir-2 were 5.1% and 3.3 cd A(-1) and 7.9% and 4.4 cd A(-1), respectively, both with saturated red emission (CIE coordinates, 0.663, 0.332). The devices have a structure of indium tin oxide/poly(3,4-ethylenedioxythio phene)/dendrimer/1,3,5-tris(N-phenylbenzimiazole-2-yl)benzene/cesium fluoride/aluminum. Given ease of synthesis and good device performance, these iridium dendrimers can be used to fully exploit the potential of low-cost OLEDs, leading to more applications in high-efficiency OLEDs. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2013.04.020
• 作为产物：
  描述：

  3-溴苯甲酰氯 、 2-苯乙胺 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 25.0h， 生成 3-溴-N-苯乙基苯甲酰胺
  参考文献：
  名称：

  [EN] INHIBITORS OF ANOCTAMIN 6 PROTEIN AND USES THEREOF
  [FR] INHIBITEURS DE LA PROTÉINE ANOCTAMINE 6 ET LEURS UTILISATIONS

  摘要：

  本发明涉及一种新化合物，可以抑制anoctamin 6蛋白质，包括该化合物的组合物，制备该化合物的方法，以及使用该化合物或组合物的方法。

  公开号：

  WO2022157686A1

文献信息

• Direct oxidative amidation of aldehydes with amines catalyzed by heteropolyanion-based ionic liquids under solvent-free conditions via a dual-catalysis process
  作者：Renzhong Fu、Yang Yang、Jin Zhang、Jintao Shao、Xuming Xia、Yunsheng Ma、Rongxin Yuan

  DOI：10.1039/c5ob02376a

  日期：——

  A simple and efficient procedure for the synthesis of amides directly from aldehydes and amines catalyzed by heteropolyanion-based ionic liquids under solvent-free conditions has been reported. The practical protocol was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, solvent-free media, and operational simplicity are the main highlights

  已经报道了一种简单有效的方法，可在无溶剂条件下直接由杂多阴离子型离子液体催化的醛和胺直接合成酰胺。发现该实用方案可耐受具有不同官能团的多种底物。主要亮点是中等至出色的产量，无溶剂介质和操作简便。简要研究了所提出的双重催化机理。此外，基于杂多阴离子的离子液体易于用于该氧化酰胺化。
• Iodine catalysed intramolecular C(sp³)–H functionalization: synthesis of 2,5-disubstituted oxazoles from N-arylethylamides
  作者：Supravat Samanta、Ramachandra Reddy Donthiri、Milan Dinda、Subbarayappa Adimurthy

  DOI：10.1039/c5ra13441b

  日期：——

  Iodine catalyzed synthesis of 2,5-substituted oxazoles from N-arylethylamides through intramolecular C(sp³)–H functionalization under metal-free conditions is described.

  碘催化合成2,5-取代噁唑，通过金属无催化条件下的分子内C(sp3)–H官能化，从N-芳基乙酰胺中进行描述。
• [EN] INHIBITORS OF ANOCTAMIN 6 PROTEIN AND USES THEREOF<br/>[FR] INHIBITEURS DE LA PROTÉINE ANOCTAMINE 6 ET LEURS UTILISATIONS
  申请人：ILDONG PHARMACEUTICAL CO LTD

  公开号：WO2022157686A1

  公开（公告）日：2022-07-28

  The present invention relates to a new compound that can inhibit an anoctamin 6 protein, a composition comprising the compound, a method for preparing the compound, and a method for using the compound or composition.

  本发明涉及一种新化合物，可以抑制anoctamin 6蛋白质，包括该化合物的组合物，制备该化合物的方法，以及使用该化合物或组合物的方法。
• [EN] INHIBITORS OF ANO6 AND THEIR USES THEREOF<br/>[FR] INHIBITEURS DE L'ANO6 ET LEURS UTILISATIONS
  申请人：[en]ILDONG PHARMACEUTICAL CO., LTD.

  公开号：WO2022195522A1

  公开（公告）日：2022-09-22

  The present invention relates to a composition comprising at least one active agent that can inhibit anoctamin 6 protein and a method of treating or preventing disease, disorder, or condition associated with virus infection by administering the composition to a subject. In addition, it relates to a method of disinfecting or sanitizing an object from virus contamination by contacting the composition with or applying the composition to an object.
• Bipolar iridium dendrimers containing carbazolyl dendron and 1,2,4-triazole unit for solution-processed saturated red electrophosphorescence
  作者：Bo Liang、Sujun Hu、Yanping Liu、Zhiqiang Fan、Xueye Wang、Weiguo Zhu、Hongbin Wu、Yong Cao

  DOI：10.1016/j.dyepig.2013.04.020

  日期：2013.10

  Two solution-processable, carbazole-based iridium dendrimers (Ir-1 and Ir-2) were synthesized and characterized. The presence of carbazolyl substituent on the cyclometallated ligand resulted in improved solubility, good control over intermolecular interactions, and improved hole transport properties. The triazole ancillary ligand led to improved electron transport properties. When the dendrimers were employed as host-free light-emitting layers in the OLEDs, the devices exhibited a low turn-on voltage of 5.4 V. The maximal external quantum efficiencies and luminous efficiency of the devices obtained from Ir-1 and Ir-2 were 5.1% and 3.3 cd A(-1) and 7.9% and 4.4 cd A(-1), respectively, both with saturated red emission (CIE coordinates, 0.663, 0.332). The devices have a structure of indium tin oxide/poly(3,4-ethylenedioxythio phene)/dendrimer/1,3,5-tris(N-phenylbenzimiazole-2-yl)benzene/cesium fluoride/aluminum. Given ease of synthesis and good device performance, these iridium dendrimers can be used to fully exploit the potential of low-cost OLEDs, leading to more applications in high-efficiency OLEDs. (C) 2013 Elsevier Ltd. All rights reserved.