N-cyclohexyl-5-cyclopropyl-3-(2-hydroxyphenyl)-1H-pyrazole-1-carboxamide | 550316-80-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-cyclohexyl-5-cyclopropyl-3-(2-hydroxyphenyl)-1H-pyrazole-1-carboxamide
• 英文别名: N-cyclohexyl-5-cyclopropyl-3-(2-hydroxyphenyl)pyrazole-1-carboxamide
• CAS: 550316-80-8
• 化学式: C₁₉H₂₃N₃O₂
• 分子量: 325.411
• InChiKey: ADAIXBSPWYAXEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  67.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1458379A1

  公开（公告）日：2004-09-22
• Hydroxphenyl-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical comositions comprising them
  申请人：PHARMACIA & UPJOHN SPA

  公开号：US20040010027A1

  公开（公告）日：2004-01-15

  The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a hydroxyphenyl-pyrazole derivative represented by formula (I): 1 wherein R 1 to R 4 independently represent hydrogen or halogen atom or a group selected from hydroxy, NO 2 , C 1 -C 6 alkyl optionally substituted with halogen atom, aryl optionally substituted with halogen atom, aryl C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, saturated or unsaturated heterocyclyl, C 1 -C 6 alkoxy, aryloxy, aryl C 1 -C 6 alkoxy or NR 8 R 9 , wherein R 8 and R 9 independently represent hydrogen, C 1 -C 6 alkyl, aryl, or a residue of formula COR 10 , CONHR 10 or SO 2 R 10 in which R 10 is hydrogen atom or C 1 -C 6 alkyl, aryl, aryl C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl or saturated or unsaturated heterocyclyl group; R 7 is a group of formula CONHR 1 , CSNHR 10 , SO 2 R 10 , COR 10 or COOR 10 , in which R 10 is as defined above, and R 5 and R 6 independently represent hydrogen or a group selected from optionally substituted C 1 -C 6 alkyl, optionally substituted aryl, aryl C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl and saturated or unsaturated heterocyclyl; and pharmaceutically acceptable salts thereof. The invention also provides compounds of formula I, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.
• [EN] HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM<br/>[FR] DERIVES D'HYDROXYPHENYL-PYRAZOLE SERVANT D'INHIBITEURS DE KINASE, PROCEDE POUR LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2003051358A1

  公开（公告）日：2003-06-26

  The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof and effective amount of o-hydroxy phenyl-pyrazol-3-yl derivatives optionally substituted of formula (I). The invention also provides some new compounds, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.