(4-methyl-3-oxazolo[5,4,b]pyridin-2-yl-phenyl)-carbamic acid prop-2-ynyl ester | 423754-92-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (4-methyl-3-oxazolo[5,4,b]pyridin-2-yl-phenyl)-carbamic acid prop-2-ynyl ester
• 英文别名: prop-2-ynyl N-[4-methyl-3-([1,3]oxazolo[5,4-b]pyridin-2-yl)phenyl]carbamate
• CAS: 423754-92-1
• 化学式: C₁₇H₁₃N₃O₃
• 分子量: 307.309
• InChiKey: YKNAGCSZZLCETP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  77.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Benzoxazole LPAAT-B inhibitors and uses thereof
  申请人：CELL THERAPEUTICS, INC.

  公开号：US20020107269A1

  公开（公告）日：2002-08-08

  The invention relates to benzoxazoles and the use thereof to inhibit lysophosphatidic acid acyltransferase &bgr; (LPAAT-&bgr;) activity. The invention further relates to methods of treating cancer using said benzoxazoles. The invention also relates to methods for screening for LPAAT-&bgr; activity.

  该发明涉及苯并噁唑及其用途，用于抑制溶磷脂酸酰基转移酶β（LPAAT-β）活性。该发明还涉及使用所述苯并噁唑治疗癌症的方法。该发明还涉及筛选LPAAT-β活性的方法。
• [EN] BENZOXAZOLE LPAAT- beta INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS BENZOXAZOLES DE LPAAT- DOLLAR G(B) ET UTILISATIONS ASSOCIEES
  申请人：BONHAM LYNN

  公开号：WO2002036580A2

  公开（公告）日：2002-05-10

  The invention relates to benzoxazoles of the following Formula, wherein the variables are defined in the claims and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity. The invention further relates to methods of treating cancer using said benzoxazoles. The invention also relates to methods for screening to LPAAT-β activitiy.
• [EN] BENZOXAZOLE LPAAT- BETA INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS BENZOXAZOLES DE LPAAT- DOLLAR G(B) ET UTILISATIONS ASSOCIEES
  申请人：——

  公开号：WO2002036580A9

  公开（公告）日：2003-02-13

  [EN] The invention relates to benzoxazoles of the following Formula, wherein the variables are defined in the claims and the use thereof to inhibit lysophosphatidic acid acyltransferase beta (LPAAT- beta ) activity. The invention further relates to methods of treating cancer using said benzoxazoles. The invention also relates to methods for screening to LPAAT- beta activitiy.
  [FR] L'invention concerne des benzoxazoles et l'utilisation de ceux-ci dans l'inhibition de l'activité de l'acide lysophosphatidique de l'acyltransférase beta (LPAAT- beta ). L'invention concerne en outre des méthodes de traitement de cancer mettant en oeuvre ces benzoxazoles. L'invention concerne enfin des méthodes de criblage de l'activité de LPAAT- beta .