methyl 2-bromo-4-(3-pyridyl)-1,3-thiazole-5-carboxylate | 1206908-41-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl 2-bromo-4-(3-pyridyl)-1,3-thiazole-5-carboxylate
• 英文别名: Methyl 2-bromo-4-(pyridin-3-yl)thiazole-5-carboxylate；methyl 2-bromo-4-pyridin-3-yl-1,3-thiazole-5-carboxylate
• CAS: 1206908-41-9
• 化学式: C₁₀H₇BrN₂O₂S
• 分子量: 299.148
• InChiKey: YESLXGBRBLENEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• PYRROLE CARBOXYLIC ACID DERIVATIVES AS ANTIBACTERIAL AGENTS
  申请人：Ranbaxy Laboratories Limited

  公开号：EP2326640A1

  公开（公告）日：2011-06-01
• [EN] PYRROLE CARBOXYLIC ACID DERIVATIVES AS ANTIBACTERIAL AGENTS<br/>[FR] DÉRIVÉS D'ACIDE PYRROLE CARBOXYLIQUE EN TANT QU'AGENTS ANTIBACTÉRIENS
  申请人：RANBAXY LAB LTD

  公开号：WO2010013222A1

  公开（公告）日：2010-02-04

  The present invention provides DNA Gyrase and/or Topo IV inhibitors of Formula (I), which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed by gram positive, gram negative and anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonus spp., Acenetobacter spp., Mυraxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Mycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Cotynebacterium, Bacillus spp., Enterobactericeae (E.coli, Klebsiella spp., Proteus spp.,etc. ) or any combination thereof. Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.