2,2-Dimethyl-propionic acid (3R,6R)-6-{(Z)-3-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-propenyl}-5,5-bis-ethylsulfanyl-tetrahydro-pyran-3-yl ester | 221373-13-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2-Dimethyl-propionic acid (3R,6R)-6-{(Z)-3-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-propenyl}-5,5-bis-ethylsulfanyl-tetrahydro-pyran-3-yl ester
• CAS: 221373-13-3
• 化学式: C₃₃H₅₄O₆S₂Si
• 分子量: 639.006
• InChiKey: QFMXXWNUMULJKF-IIGGEZCHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.39
• 重原子数：
  42.0
• 可旋转键数：
  11.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  63.22
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-propionic acid (3R,6R)-6-{(Z)-3-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-propenyl}-5,5-bis-ethylsulfanyl-tetrahydro-pyran-3-yl ester 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以98%的产率得到2,2-Dimethyl-propionic acid (3R,6R)-5,5-bis-ethylsulfanyl-6-[(Z)-3-((2R,4S,5R)-5-hydroxy-2-phenyl-[1,3]dioxan-4-yl)-propenyl]-tetrahydro-pyran-3-yl ester
  参考文献：
  名称：

  Total Synthesis of Brevetoxin A: Part 1: First Generation Strategy and Construction of BCD Ring System

  摘要：

  Discussed herein is our first generation strategy for the total synthesis of brevetoxin A. This approach relies upon dissection of the molecule at the nine-membered ring site (ring E), A Wittig coupling of requisite polycyclic fragments 3 and 4 followed by hydroxy dithioketal cyclization was expected to furnish the polycyclic framework of brevetoxin A (1). Intermediate 8 was anticipated to be a valid synthetic precursor to phosphonium salt 3, and its synthesis was accomplished by a bis(lactonization)/thionolactone formation/functionalization sequence. In order to test our synthetic strategy, the synthesis of an advanced model system (36) was attempted. Aldehyde 38 and phosphonium salt 37 were successfully synthesized and coupled through a:Wittig reaction. Unfortunately, the planned hydroxy dithioketal cyclization to form the crucial nonacene (ring E) did not proceed as anticipated and this synthetic approach was discontinued.

  DOI：

  10.1002/(sici)1521-3765(19990201)5:2<599::aid-chem599>3.0.co;2-n
• 作为产物：
  描述：

  [(3R,6R)-5,5-bis(ethylsulfanyl)-6-(hydroxymethyl)oxan-3-yl] 2,2-dimethylpropanoate 在 六甲基磷酰三胺 、 正丁基锂 、 pyridine-SO3 complex 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 15.0h， 生成 2,2-Dimethyl-propionic acid (3R,6R)-6-{(Z)-3-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-propenyl}-5,5-bis-ethylsulfanyl-tetrahydro-pyran-3-yl ester
  参考文献：
  名称：

  Total Synthesis of Brevetoxin A: Part 1: First Generation Strategy and Construction of BCD Ring System

  摘要：

  Discussed herein is our first generation strategy for the total synthesis of brevetoxin A. This approach relies upon dissection of the molecule at the nine-membered ring site (ring E), A Wittig coupling of requisite polycyclic fragments 3 and 4 followed by hydroxy dithioketal cyclization was expected to furnish the polycyclic framework of brevetoxin A (1). Intermediate 8 was anticipated to be a valid synthetic precursor to phosphonium salt 3, and its synthesis was accomplished by a bis(lactonization)/thionolactone formation/functionalization sequence. In order to test our synthetic strategy, the synthesis of an advanced model system (36) was attempted. Aldehyde 38 and phosphonium salt 37 were successfully synthesized and coupled through a:Wittig reaction. Unfortunately, the planned hydroxy dithioketal cyclization to form the crucial nonacene (ring E) did not proceed as anticipated and this synthetic approach was discontinued.

  DOI：

  10.1002/(sici)1521-3765(19990201)5:2<599::aid-chem599>3.0.co;2-n