3-diethylaminopropane-1-sulfonic acid {(R)-1-[5-(3-cyano-4-methoxyphenyl)-2H-[1,2,4]triazol-3-yl]-3-phenylpropyl}amide | 957068-20-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-diethylaminopropane-1-sulfonic acid {(R)-1-[5-(3-cyano-4-methoxyphenyl)-2H-[1,2,4]triazol-3-yl]-3-phenylpropyl}amide
• 英文别名: N-[(1R)-1-[3-(3-cyano-4-methoxyphenyl)-1H-1,2,4-triazol-5-yl]-3-phenylpropyl]-3-(diethylamino)propane-1-sulfonamide
• CAS: 957068-20-1
• 化学式: C₂₆H₃₄N₆O₃S
• 分子量: 510.66
• InChiKey: LRTWTRXVZXTOSV-HSZRJFAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  36
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• SULFONAMIDE COMPOUNDS AND USES THEREOF
  申请人：Saunders Jeffrey O.

  公开号：US20110152232A1

  公开（公告）日：2011-06-23

  Compounds that modulate GHS-R are described, for examples compounds formula (I)

  调节GHS-R的化合物已被描述，例如化合物公式(I)。
• METHODS OF TREATING MILD BRAIN INJURY
  申请人：Oxeia Biopharmaceuticals Inc.

  公开号：EP3182992A1

  公开（公告）日：2017-06-28
• [EN] METHODS OF TREATING MILD BRAIN INJURY<br/>[FR] MÉTHODES DE TRAITEMENT D'UNE LÉSION CÉRÉBRALE LÉGÈRE
  申请人：OXEIA BIOPHARMACEUTICALS INC

  公开号：WO2016028826A1

  公开（公告）日：2016-02-25

  The present disclosure provides methods for treating mild brain injury and other neurological disorders in a subject in need thereof, comprising administering to the subject an effective amount of a compound comprising a ghrelin or ghrelin variant. This invention provides for methods for treating a mild brain injury or concussion in a patient wherein said method comprises administering to the subject in need thereof suffering from said mild brain injury or concussion an effective amount of a ghrelin variant or a composition comprising a ghrelin variant so as to treat said mild brain injury or concussion.