(R)-N-[1-(3,5-difluoro-4-methanesulfonylarmino-phenyl)-ethyl]-2-(3,4-difluorobenzyl)-thiazole-4-amide | 1202643-16-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (R)-N-[1-(3,5-difluoro-4-methanesulfonylarmino-phenyl)-ethyl]-2-(3,4-difluorobenzyl)-thiazole-4-amide
• 英文别名: N-[(1R)-1-[3,5-difluoro-4-(methanesulfonamido)phenyl]ethyl]-2-[(3,4-difluorophenyl)methyl]-1,3-thiazole-4-carboxamide
• CAS: 1202643-16-0
• 化学式: C₂₀H₁₇F₄N₃O₃S₂
• 分子量: 487.499
• InChiKey: XUFHZDDOYVVQOZ-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
  申请人：Woo Byoung Young

  公开号：US20110152318A1

  公开（公告）日：2011-06-23

  This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.

  本发明涉及一种新型化合物，其异构体或其药学上可接受的盐作为vanilloid受体（Vanilloid Receptor 1; VR1; TRPV1）拮抗剂；以及包含该化合物的制药组合物。本发明提供了一种用于预防或治疗疾病的制药组合物，例如疼痛、偏头痛、关节痛、神经痛、神经病、神经损伤、皮肤疾病、膀胱过敏、肠易激综合症、排便紧迫、呼吸系统疾病、皮肤、眼或黏膜刺激、胃十二指肠溃疡、炎症性疾病、耳病、心脏病等疾病。
• SULPHONAMIDES AS VANILLOID RECEPTOR ANTAGONIST
  申请人：Amorepacific Corporation

  公开号：EP2307394B1

  公开（公告）日：2012-09-26