1-phenyl-1H-[1,2,4]triazole-3-carboxylic acid amide | 111340-56-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-phenyl-1H-[1,2,4]triazole-3-carboxylic acid amide
• 英文别名: 1-Phenyl-1H-[1,2,4]triazol-3-carbonsaeure-amid；1-Phenyl-1,2,4-triazole-3-carboxamide
• CAS: 111340-56-8
• 化学式: C₉H₈N₄O
• 分子量: 188.189
• InChiKey: XPQPQWHXMJIDQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 氨 、 水 作用下， 生成 1-phenyl-1H-[1,2,4]triazole-3-carboxylic acid amide
  参考文献：
  名称：

  Bladin, Chemische Berichte, 1890, vol. 23, p. 1812

  摘要：

  DOI：

文献信息

• Cyclin Based Inhibitors of CDK2 and CDK4
  申请人：McInnes Campbell

  公开号：US20130289240A1

  公开（公告）日：2013-10-31

  Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation.

  研究了肽抑制剂与环D和环A凹槽的结构和功能分析，并用于设计肽，为结构活性关系提供基础，改善结合并具有作为化学生物学探针、潜在诊断和治疗增殖性疾病（包括癌症和炎症）的潜力。
• 1-phenyl-5-substituted-1H-1, 2,4-triazole-3-carboxamide derivates, process for preparation of the same, and fungicidal composition comprising the same
  申请人：KUREHA CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0562480B1

  公开（公告）日：1997-01-02
• DALLACKER F.; MINN K., CHEM.-ZTG, 110,(1986) N 7-8, 275-281
  作者：DALLACKER F.、 MINN K.

  DOI：——

  日期：——
• JPH06279420A
  申请人：——

  公开号：JPH06279420A

  公开（公告）日：1994-10-04
• CYCLIN BASED INHIBITORS OF CDK2 AND CDK4
  申请人：University of South Carolina

  公开号：US20170218018A1

  公开（公告）日：2017-08-03

  Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation.