3-环基吡唑 | 476629-87-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 3-环基吡唑
• 英文名称: 3-cyclopentyl-1H-pyrazole
• 英文别名: 5-cyclopentyl-1H-pyrazole
• CAS: 476629-87-5
• 化学式: C₈H₁₂N₂
• 分子量: 136.19
• InChiKey: DTJJREHRTQMDJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• THERAPEUTIC COMPOUNDS
  申请人：CELGENE QUANTICEL RESEARCH, INC.

  公开号：US20180296543A1

  公开（公告）日：2018-10-18

  The present embodiments relate to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease. Particular compounds described herein exhibit selective inhibitory activity against CBP compared with BRD4.

  本发明涉及取代杂环衍生物治疗性化合物，包括所述化合物的组合物，以及通过抑制溴结构域介导的乙酰赖氨酸蛋白区域（如组蛋白）的识别，来用于表观遗传调控的所述化合物和组合物。所述组合物和方法对于治疗由异常细胞信号介导的疾病，如炎症性疾病、癌症和肿瘤性疾病，是有用的。特别是，此处描述的某些化合物对CBP显示出相对于BRD4的选择性抑制活性。
• [EN] N-PYRIDINYL ACETAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY<br/>[FR] DÉRIVÉS DE N-PYRIDYL ACÉTAMIDE UTILISÉS COMME INHIBITEURS DE LA VOIE DE SIGNALISATION WNT
  申请人：REDX PHARMA PLC

  公开号：WO2016055786A1

  公开（公告）日：2016-04-14

  This invention relates to compounds. More specifically, the invention relates to compounds useful as inhibitors of the Wnt signalling pathway. Specifically, inhibitors of Porcupine (Porcn) are contemplated by the invention. In addition the invention contemplates processes to prepare the compounds and uses of the compounds. The compounds of the invention may therefore be used in treating conditions mediated by the Wnt signalling pathway, for example treating cancer, sarcoma, melanoma, skin cancer, haematological tumors, lymphoma, carcinoma, and leukemia; or enhancing the effectiveness of an anti-cancer treatment.

  这项发明涉及化合物。更具体地，该发明涉及作为Wnt信号通路抑制剂的化合物。具体来说，该发明考虑了Porcupine（Porcn）的抑制剂。此外，该发明考虑了制备这些化合物的过程以及这些化合物的用途。因此，该发明的化合物可用于治疗由Wnt信号通路介导的疾病，例如治疗癌症、肉瘤、黑色素瘤、皮肤癌、血液肿瘤、淋巴瘤、癌症和白血病；或增强抗癌治疗的有效性。
• Aldosterone Synthase Inhibitor
  申请人：Bell Michael Gregory

  公开号：US20120322841A1

  公开（公告）日：2012-12-20

  The present invention provides aldosterone synthase inhibitors of the formula: intermediates, methods for their preparation, pharmaceutical preparations, and methods for their use.

  这项发明提供了以下结构的醛固酮合成酶抑制剂： 中间体，其制备方法，药物制剂以及使用方法。
• [EN] HETEROCYCLIC APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF<br/>[FR] AGONISTES DU RÉCEPTEUR DE L'APÉLINE (APJ) HÉTÉROCYCLIQUE ET LEURS UTILISATIONS
  申请人：RES TRIANGLE INST

  公开号：WO2018071526A1

  公开（公告）日：2018-04-19

  This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.

  这项披露涉及具有杂环核的Aplin受体（APJ）激动剂以及这些激动剂的用途。
• Tetrahydro-cyclopentyl pyrazole cannabinoid modulators
  申请人：Liotta Fina

  公开号：US20070191362A1

  公开（公告）日：2007-08-16

  This invention is directed to a tetrahydro-cyclopentyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.

  本发明涉及一种式子为(I)的四氢-环戊基吡唑类大麻素调节剂化合物，以及一种用于治疗、改善或预防大麻素受体介导的综合症、疾病或疾病的方法。