Methyl 2-(3-cyano-4-hydroxyphenyl)-4-ethyl-1,3-thiazole-5-carboxylate | 934470-41-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Methyl 2-(3-cyano-4-hydroxyphenyl)-4-ethyl-1,3-thiazole-5-carboxylate
• CAS: 934470-41-4
• 化学式: C₁₄H₁₂N₂O₃S
• 分子量: 288.327
• InChiKey: UOUDGZRLKVIOJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• AGENT FOR TREATING OR PREVENTING DIGESTIVE ULCER
  申请人：Kawakami Masakatsu

  公开号：US20110281919A1

  公开（公告）日：2011-11-17

  An object of the present invention is to provide an agent for treating or preventing digestive ulcer that is effective even to ulcer of small intestine and others, for which gastric acid secretion inhibitors such as proton pump inhibitors are ineffective, and is superior to allopurinol in the efficaciousness and the safety. The pharmaceutical composition of the present invention comprising a non-purine xanthine oxidase inhibitor as the active ingredient is useful as an agent for treating or preventing ulcer that forms in digestive tracts by the attack of gastric acid, pepsin, stress, Helicobacter pylori bacteria, NSAID, etc. In particular, it is useful as an ulcer remedy heretofore unknown in the art as it is effective even for ulcer in small intestine for which gastric/duodenal ulcer remedies that inhibit gastric acid secretion such as proton pump inhibitors are ineffective.

  本发明的目的是提供一种治疗或预防消化性溃疡的药剂，即使对于质子泵抑制剂无效的小肠溃疡等其他类型的溃疡也具有有效性，并且在功效和安全性方面优于丙戊酸和。本发明的药物组合物包括一种非嘌呤黄嘌呤氧化酶抑制剂作为活性成分，对于由胃酸、胃蛋白酶、应激、幽门螺杆菌、非甾体消炎药等攻击消化道而形成的溃疡具有治疗或预防作用。特别是，对于质子泵抑制剂等抑制胃酸分泌的胃/十二指肠溃疡药物无效的小肠溃疡等，它是迄今为止在技术上未知的溃疡治疗方法，具有有效性。
• Remedy or preventive for digestive ulcer
  申请人：Astellas Pharma Inc.

  公开号：EP1992361B1

  公开（公告）日：2012-05-02
• EP1992361A1
  申请人：——

  公开号：EP1992361A1

  公开（公告）日：2008-11-19
• US8426453B2
  申请人：——

  公开号：US8426453B2

  公开（公告）日：2013-04-23