5',5'''-bis(2,6-diisopropylphenyl)-2,6,2'''',6''''-tetraisopropyl-m-quinquephenyl-2''-yl iodide | 362011-06-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5',5'''-bis(2,6-diisopropylphenyl)-2,6,2'''',6''''-tetraisopropyl-m-quinquephenyl-2''-yl iodide
• 英文别名: 1,3-Bis[3,5-bis[2,6-di(propan-2-yl)phenyl]phenyl]-2-iodobenzene
• CAS: 362011-06-1
• 化学式: C₆₆H₇₇I
• 分子量: 997.242
• InChiKey: JICDOMWNFUGUNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  21.3
• 重原子数：
  67
• 可旋转键数：
  14
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  5',5'''-bis(2,6-diisopropylphenyl)-2,6,2'''',6''''-tetraisopropyl-m-quinquephenyl-2''-yl iodide 在 1,2,3,4,5,6,7,8-八硫杂环辛烷 、 叔丁基锂 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以63%的产率得到2,6-Bis[3,5-bis[2,6-di(propan-2-yl)phenyl]phenyl]benzenethiol
  参考文献：
  名称：

  A novel dendrimer-type m-terphenyl substituent for the kinetic stabilization of highly reactive species

  摘要：

  A novel m-terphenyl-based steric protection group (Bpq group) bearing a dendrimer-type framework was designed and successfully applied to the stabilization of the corresponding N-thiosulfinylaniline and arenesulfenyl iodide. The Bpq group was found to provide a very inert environment for the reactive functionality embedded in its clef. (C) 2001 Elsevier Science Ltd. Ail rights reserved.

  DOI：

  10.1016/s0040-4039(01)00871-1
• 作为产物：
  描述：

  2,4,6-溴碘苯 在 magnesium 作用下， 以 四氢呋喃 为溶剂， 生成 5',5'''-bis(2,6-diisopropylphenyl)-2,6,2'''',6''''-tetraisopropyl-m-quinquephenyl-2''-yl iodide
  参考文献：
  名称：

  A novel dendrimer-type m-terphenyl substituent for the kinetic stabilization of highly reactive species

  摘要：

  A novel m-terphenyl-based steric protection group (Bpq group) bearing a dendrimer-type framework was designed and successfully applied to the stabilization of the corresponding N-thiosulfinylaniline and arenesulfenyl iodide. The Bpq group was found to provide a very inert environment for the reactive functionality embedded in its clef. (C) 2001 Elsevier Science Ltd. Ail rights reserved.

  DOI：

  10.1016/s0040-4039(01)00871-1

文献信息

• Isolation of a <i>Se-</i>Nitrososelenol:  A New Class of Reactive Nitrogen Species Relevant to Protein <i>Se-</i>Nitrosation
  作者：Keiichi Shimada、Kei Goto、Takayuki Kawashima、Nozomi Takagi、Yoong-Kee Choe、Shigeru Nagase

  DOI：10.1021/ja0457009

  日期：2004.10.1

  Nitric oxide (NO) is a messenger molecule implicated in a number of physiological processes. Nitrosation of selenoproteins has been suggested as playing an important role in NO-mediated cellular functions such as the inactivation of glutathione peroxidase (GPx), but no chemical information about Se-nitrosated species has been available to date. Here a stable Se-nitrososelenol (RSeNO), a new class of NO derivative, was synthesized and fully characterized by X-ray crystallography and spectroscopic methods. This Se-nitrososelenol can be formed by direct transnitrosation from an S-nitrosothiol to a selenol, as is the case in the proposed mechanism for the NO-mediated inactivation of GPx.