hexahydro-2-oxo-1,3,5,5-tetramethyl-1,3,5-triazonium iodide | 130750-13-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪烷类
• 英文名称: hexahydro-2-oxo-1,3,5,5-tetramethyl-1,3,5-triazonium iodide
• 英文别名: 1,3,5,5-tetramethyl-1,3,5-triazinan-5-ium-2-one;iodide
• CAS: 130750-13-9
• 化学式: C₇H₁₆N₃O*I
• 分子量: 285.128
• InChiKey: JFAMWEYXTFMOGS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.02
• 重原子数：
  12.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  23.55
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  hexahydro-2-oxo-1,3,5-trimethyl-1,3,5-triazine 、 碘甲烷 反应 1.0h， 以100%的产率得到hexahydro-2-oxo-1,3,5,5-tetramethyl-1,3,5-triazonium iodide
  参考文献：
  名称：

  Amino protection using triazones

  摘要：

  DOI：

  10.1016/0040-4039(90)80084-y

文献信息

• Synthesis of hypusine and other polyamines using dibenzyltriazones for amino protection
  作者：Spencer Knapp、Jeffrey J. Hale、Margarita Bastos、Audrey Molina、Kuang Yu Chen

  DOI：10.1021/jo00049a036

  日期：1992.11

  The use of 1,3-dibenzyl-5-substituted-hexahydro-2-oxo-1,3,5-triazine ("dibenzyltriazone") as a protecting group for primary amino is described. Optimized conditions for formation and hydrolysis of dibenzyltriazones, as well as a variety of transformations (reduction, oxidation, hydroxyl modification, C-C bond formation) compatible with this protecting group, are presented. N-Protected amino aldehydes such as 46, 47, and 94 are particularly valuable building blocks, as demonstrated by the syntheses of hypusine (86), deoxyhypusine (85), spermidine (74), and two unsaturated spermidine analogues 81 and 84.