3-(3,4-dichlorophenyl)-1-(1-methyl-4-piperidinyl)-1H-pyrazolo[4,3-c]pyridine | 153713-93-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(3,4-dichlorophenyl)-1-(1-methyl-4-piperidinyl)-1H-pyrazolo[4,3-c]pyridine
• 英文别名: 3-(3,4-Dichlorophenyl)-1-(1-methylpiperidin-4-yl)pyrazolo[4,3-c]pyridine
• CAS: 153713-93-0
• 化学式: C₁₈H₁₈Cl₂N₄
• 分子量: 361.274
• InChiKey: BCOHNJQZNDOYSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  34
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NEW COMPOUNDS II
  申请人：Savory Edward

  公开号：US20110195992A1

  公开（公告）日：2011-08-11

  The present invention relates to compounds of formula (I), and their pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers or N-oxides, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment of medical conditions wherein inhibition of SSAO activity is beneficial, such as such as inflammatory diseases and immune disorders.

  本发明涉及式(I)的化合物及其药学上可接受的盐、溶剂化合物、水合物、几何异构体、互变异构体、光学异构体或N-氧化物，它们是SSAO活性抑制剂。本发明还涉及包含这些化合物的制药组合物以及利用这些化合物治疗抑制SSAO活性有益的医疗状况，例如炎症性疾病和免疫性疾病。
• New Compounds II
  申请人：Proximagen Ltd

  公开号：US20140107150A1

  公开（公告）日：2014-04-17

  The present invention relates to compounds of formula (I), and their pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers or N-oxides, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment of medical conditions wherein inhibition of SSAO activity is beneficial, such as such as inflammatory diseases and immune disorders.

  本发明涉及化合物(I)及其药学上可接受的盐、溶剂合物、水合物、几何异构体、互变异构体、光学异构体或N-氧化物，这些化合物是SSAO活性的抑制剂。本发明还涉及包含这些化合物的药物组合物以及利用这些化合物治疗抑制SSAO活性有益的医疗条件，例如炎症性疾病和免疫障碍。
• Pyrazolo 4,3-c pyridines, a process for their preparation and their use as serotonin reuptake inhibitors
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0594001A1

  公开（公告）日：1994-04-27

  The invention relates to compounds of the frmula wherein    Ar is or pyridyl;    R₁ is H,-(CH₂)pNR₂R₃,    R₂ is hydrogen or loweralkyl;    R₃ is hydrogen or loweralkyl;    R₄ is hydrogen or loweralkyl;    X and Y are independently halogen, trifluoromethyl, nitro, loweralkyl, loweralkoxy or hydroxy;    n is 0, 1, 2 or 3;    m is 0, 1 or 2;    p and q are independently 2, 3 or 4;    or a pharmaceutically acceptable addition salt and/or hydrate thereof, or where applicable, a geometric or optical isomer or racemic mixture thereof. This invention also relates to a process for making the compounds and to pharmaceutical compositions, and to their use as serotonin reuptake inhibitors.

  本发明涉及下列化合物 其中 Ar 是 或吡啶基； R₁ 是 H、-(CH₂)pNR₂R₃、 R₂ 是氢或低级烷基； R₃ 是氢或低级烷基； R₄ 是氢或低级烷基； X 和 Y 独立地为卤素、三氟甲基、硝基、低级烷基、低级烷氧基或羟基； n 是 0、1、2 或 3； m 是 0、1 或 2； p 和 q 独立地为 2、3 或 4； 或其药学上可接受的加成盐和/或水合物，或（如适用）其几何或光学异构体或外消旋混合物。 本发明还涉及制造这些化合物的工艺和药物组合物，以及它们作为血清素再摄取抑制剂的用途。
• Pyrazolo[4,3-c]pyridine compounds and their use as inhibitors of SSAO
  申请人：Proximagen Limited

  公开号：EP2328895B1

  公开（公告）日：2013-03-27
• US5296491A
  申请人：——

  公开号：US5296491A

  公开（公告）日：1994-03-22