4-pyrrolidino-2-heptene | 23516-90-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4-pyrrolidino-2-heptene
• 英文别名: 1-(1-Propyl-1-buten-1-yl)pyrrolidine；1-hept-3-en-4-ylpyrrolidine
• CAS: 23516-90-7
• 化学式: C₁₁H₂₁N
• 分子量: 167.294
• InChiKey: FCLJDKUBFUKOAM-UHFFFAOYSA-N

物化性质

• 沸点：
  56-58 °C(Press: 0.2 Torr)
• 密度：
  0.881±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-pyrrolidino-2-heptene 、 5-hydroxymethyl-1-methyl-2,3-diphenyl-1H-indole-4,7-dione 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以66%的产率得到8-ethyl-1-methyl-2,3-diphenyl-7-propyl-1H,5H-pyrano[3,4-f]indole-4,9-dione
  参考文献：
  名称：

  Reactions of 5-Hydroxymethyl-1H-indole-4,7-dione with Enamines for the First Construction of 1H,5H-Pyrano[3,4-f]indole-4,9-dione Derivatives

  摘要：

  5-Hydroxymethyl-1-methyl-2,3-diphenyl-IH-indole-4,7-dione (4) was synthesized and the tandem Michael addition/cyclization sequence between this indolequinone and enamines has been used to construct title pyranoindolequinone derivatives (6), (7), and (9).

  DOI：

  10.3987/com-04-10102
• 作为产物：
  描述：

  四氢吡咯 、 4-庚酮 在 牛血清白蛋白 、 碘甲烷 作用下， 以 Petroleum ether 为溶剂， 反应 2.5h， 以85%的产率得到4-pyrrolidino-2-heptene
  参考文献：
  名称：

  Preparation of Enamines by the Reaction of Ketones and Secondary Amines with Silylating Agents

  摘要：

  DOI：

  10.1021/jo9712613

文献信息

• Diels-Alder Reaction of 1,2,3-Benzotriazine with Enamine: Application to the Synthesis of Alkaloids, 2-Propylquinoline and 2-Pentylquinoline.
  作者：Junko KOYAMA、Izumi TOYOKUNI、Kiyoshi TAGAHARA

  DOI：10.1248/cpb.46.332

  日期：——

  The Diels-Alder reaction of 1, 2, 3-benzotriazine with several pyrrolidine enamines of carbonyl compounds was carried out in chloroform in the presence of zinc bromide to afford 2- or 3-mono-, or 2, 3-disubstituted quinolines. This method was applied to the synthesis of the alkaloids, 2-propylquinoline and 2-pentylquinoline.

  1, 2, 3-苯并三嗪与几种羰基化合物的哌啶亚胺在氯仿中与溴化锌反应，进行了Diels-Alder反应，得到了2或3-单取代或2, 3-双取代的喹啉。该方法被用于合成生物碱2-丙基喹啉和2-戊基喹啉。
• Synthesis of 1-amino- and 1-hydroxy-9,10-anthraquinone derivatives based on reaction sequences between 2-acetyl-1,4-naphthoquinone and enamines
  作者：Kazuhiro Kobayashi、Masaharu Uchida、Shinya Watanabe、Atsushi Takanohashi、Miyuki Tanmatsu、Osamu Morikawa、Hisatoshi Konishi

  DOI：10.1016/s0040-4039(00)00168-4

  日期：2000.4

  2-Acetyl-1,4-naphthoquinone was treated with pyrrolidine (or morpholine) enamines, derived from cyclic and acyclic ketones, in DMF at room temperature for 24-72 h to afford 3,4-disubstituted 1-pyrrolidino(or morpholino)-9,10-anthraquinones. On the other hand, when the treatment of 2-acetyl-1,4-naphthoquinone with enamines for 2 min was followed by addition of water and heating at 100 degrees C for 2 h, the corresponding 1-hydroxy-9,10-naphthoquinone derivatives were obtained. (C) 2000 Elsevier Science Ltd. All rights reserved.