2-[(furan-2-yl)-hydroxy-methyl]-malonic acid di-tert-butyl ester | 1204142-59-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 2-[(furan-2-yl)-hydroxy-methyl]-malonic acid di-tert-butyl ester
• 英文别名: Ditert-butyl 2-[furan-2-yl(hydroxy)methyl]propanedioate
• CAS: 1204142-59-5
• 化学式: C₁₆H₂₄O₆
• 分子量: 312.363
• InChiKey: HYYSZVLQMUGNJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  86
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  三甲基氯硅烷 、 2-[(furan-2-yl)-hydroxy-methyl]-malonic acid di-tert-butyl ester 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-[(furan-2-yl)-(trimethylsiloxy)-methyl]-malonic-acid di-tert-butyl ester
  参考文献：
  名称：

  Synthesis of β-hydroxymalonates: the direct aldol addition of malonates to aldehydes in the presence of SiCl4 and i-Pr2EtN

  摘要：

  The direct aldol addition of malonates to aromatic, hetero-aromatic and unsaturated aldehydes leading to beta-hydroxymalonates is described. The stability of these products, the trimethyl silyl protection of the hydroxyl group as well as the role of both SiCl4 and i-Pr2EtN in attaining the final products are also discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.10.057
• 作为产物：
  描述：

  在 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 生成 2-[(furan-2-yl)-hydroxy-methyl]-malonic acid di-tert-butyl ester
  参考文献：
  名称：

  Synthesis of β-hydroxymalonates: the direct aldol addition of malonates to aldehydes in the presence of SiCl4 and i-Pr2EtN

  摘要：

  The direct aldol addition of malonates to aromatic, hetero-aromatic and unsaturated aldehydes leading to beta-hydroxymalonates is described. The stability of these products, the trimethyl silyl protection of the hydroxyl group as well as the role of both SiCl4 and i-Pr2EtN in attaining the final products are also discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.10.057

文献信息

• Synthesis of β-hydroxymalonates: the direct aldol addition of malonates to aldehydes in the presence of SiCl4 and i-Pr2EtN
  作者：Antonio Massa、Arrigo Scettri、Rosanna Filosa、Laura Capozzolo

  DOI：10.1016/j.tetlet.2009.10.057

  日期：2009.12

  The direct aldol addition of malonates to aromatic, hetero-aromatic and unsaturated aldehydes leading to beta-hydroxymalonates is described. The stability of these products, the trimethyl silyl protection of the hydroxyl group as well as the role of both SiCl4 and i-Pr2EtN in attaining the final products are also discussed. (C) 2009 Elsevier Ltd. All rights reserved.