Boc-Ala-Arg(NO2)-Ala-Pro-Lys(Z)-OBzl | 713524-17-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Ala-Arg(NO2)-Ala-Pro-Lys(Z)-OBzl
• CAS: 713524-17-5
• 化学式: C₄₃H₆₂N₁₀O₁₂
• 分子量: 911.025
• InChiKey: VABZIHALZIFFIF-XVZWFMNBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.29
• 重原子数：
  65.0
• 可旋转键数：
  23.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  301.62
• 氢给体数：
  8.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  Boc-Ala-Arg(NO2)-Ala-Pro-Lys(Z)-OBzl 在 palladium on activated charcoal 甲酸 、 氢气 作用下， 反应 24.0h， 以92%的产率得到(S)-6-Amino-2-[((S)-1-{(S)-2-[(S)-2-((S)-2-amino-propionylamino)-5-guanidino-pentanoylamino]-propionyl}-pyrrolidine-2-carbonyl)-amino]-hexanoic acid
  参考文献：
  名称：

  The composition and sequence specificity of Pro-Ala-Lys-OH for the thrombolytic activities of P6A and related oligopeptides

  摘要：

  The in vitro and in vivo thrombolytic activities of Ala-Arg-Pro-Ala-Lys-OH, its analogs and the related peptides were assayed. The results indicate that when (5)Lys of Ala-Arg-Pro-Ala-Lys-OH is changed into (5)Arg, and (5)Lys of Pro-Ala-Lys-OH is changed into (3)Arg the thrombolytic activities are collapsed; when Pro-Ala-Lys-OH is changed into Ala-Pro-Lys-OH, and Ala-Arg-Pro-Ala-Lys-OH is changed into Ala-Arg-Ala-Pro-Lys-OH the thrombolytic activities are also collapsed; when (5)nLys of Ala-Arg-Pro-Ala-Lys-OH is changed into (5)nLeu the thrombolytic activities are again collapsed. All of the results indicate that for the thrombolytic activities of Ala-Arg-Pro-Ala-Lys-OH and the related peptides Pro-Ala-Lys-OH exhibits either amino acid composition specificity or sequence specificity. The composition and sequence specificity of Pro-Ala-Lys-OH reflects its rule as the pharmacophore of P6A and the related peptides. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.02.011
• 作为产物：
  描述：

  N'-硝基-L-精氨酸苄酯 在 sodium hydroxide 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 98.0h， 生成 Boc-Ala-Arg(NO2)-Ala-Pro-Lys(Z)-OBzl
  参考文献：
  名称：

  The composition and sequence specificity of Pro-Ala-Lys-OH for the thrombolytic activities of P6A and related oligopeptides

  摘要：

  The in vitro and in vivo thrombolytic activities of Ala-Arg-Pro-Ala-Lys-OH, its analogs and the related peptides were assayed. The results indicate that when (5)Lys of Ala-Arg-Pro-Ala-Lys-OH is changed into (5)Arg, and (5)Lys of Pro-Ala-Lys-OH is changed into (3)Arg the thrombolytic activities are collapsed; when Pro-Ala-Lys-OH is changed into Ala-Pro-Lys-OH, and Ala-Arg-Pro-Ala-Lys-OH is changed into Ala-Arg-Ala-Pro-Lys-OH the thrombolytic activities are also collapsed; when (5)nLys of Ala-Arg-Pro-Ala-Lys-OH is changed into (5)nLeu the thrombolytic activities are again collapsed. All of the results indicate that for the thrombolytic activities of Ala-Arg-Pro-Ala-Lys-OH and the related peptides Pro-Ala-Lys-OH exhibits either amino acid composition specificity or sequence specificity. The composition and sequence specificity of Pro-Ala-Lys-OH reflects its rule as the pharmacophore of P6A and the related peptides. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.02.011