4-(6-(2-Methoxyethylamino)imidazo[1,2-b]pyridazin-3-yl)benzonitrile | 1082604-67-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(6-(2-Methoxyethylamino)imidazo[1,2-b]pyridazin-3-yl)benzonitrile
• 英文别名: 4-[6-(2-methoxyethylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile
• CAS: 1082604-67-8
• 化学式: C₁₆H₁₅N₅O
• 分子量: 293.328
• InChiKey: JODYSDJXVCGOTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  75.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(6-chloroimidazo[1,2-b]pyridazin-3-yl)benzonitrile 、 2-甲氧基乙胺 以 N-甲基吡咯烷酮 为溶剂， 反应 0.5h， 生成 4-(6-(2-Methoxyethylamino)imidazo[1,2-b]pyridazin-3-yl)benzonitrile
  参考文献：
  名称：

  Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7

  摘要：

  A high-throughput screening campaign identified a number of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7. Further synthetic chemistry efforts enabled the preparation of a number of analogues with promising in vitro potencies. Although these compounds show likely broad spectrum inhibitory activity, they represent a useful starting point for further chemical optimisation. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.043

文献信息

• Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7
  作者：Nathalie Bouloc、Jonathan M. Large、Ela Smiljanic、David Whalley、Keith H. Ansell、Christopher D. Edlin、Justin S. Bryans

  DOI：10.1016/j.bmcl.2008.08.043

  日期：2008.10

  A high-throughput screening campaign identified a number of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7. Further synthetic chemistry efforts enabled the preparation of a number of analogues with promising in vitro potencies. Although these compounds show likely broad spectrum inhibitory activity, they represent a useful starting point for further chemical optimisation. (c) 2008 Elsevier Ltd. All rights reserved.