2-fluoro-5-(2-(1-(4-fluorophenyl)-2-((2-(4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1H-imidazol-5-yl)propan-2-yl)benzonitrile | 1430210-90-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-fluoro-5-(2-(1-(4-fluorophenyl)-2-((2-(4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1H-imidazol-5-yl)propan-2-yl)benzonitrile
• 英文别名: 2-Fluoro-5-[2-[3-(4-fluorophenyl)-2-[2-[4-(2-methylimidazol-1-yl)phenoxy]ethylsulfanyl]imidazol-4-yl]propan-2-yl]benzonitrile
• CAS: 1430210-90-4
• 化学式: C₃₁H₂₇F₂N₅OS
• 分子量: 555.651
• InChiKey: SORGQDTVUPXTAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  94
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME<br/>[FR] COMPOSÉS INDAZOLE UTILISÉS COMME INHIBITEURS DE KINASE ET MÉTHODE DE TRAITEMENT DU CANCER AVEC LESDITS COMPOSÉS
  申请人：UNIV HEALTH NETWORK

  公开号：WO2013053051A1

  公开（公告）日：2013-04-18

  The present teaching provide indazole compounds represented by Structural Formulae (I) or (I') or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as TTK protein kinase, polo-like kinase 4 (PLK4) and Aurora kinases having anticancer activity against breast cancer cells, colon cancer cells, and ovarian cancer cells.

  本教学提供了由结构式（I）或（I'）表示的吲唑化合物或其药用可接受的盐。还描述了这些药物组合物及其用作蛋白激酶抑制剂的方法，如对乳腺癌细胞、结肠癌细胞和卵巢癌细胞具有抗癌活性的TTK蛋白激酶、极化样激酶4（PLK4）和极化激酶。
• [EN] 2-THIO-IMIDAZOLE DERIVATIVES AS TGR5 MODULATORS<br/>[FR] DÉRIVÉS DE 2-THIOL-IMIDAZOLE UTILES COMME MODULATEURS DE TGR5
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2013054338A1

  公开（公告）日：2013-04-18

  The present invention relates to compounds of the general Formula I their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers, prodrugs, their N-oxide, metabolites, polymorphs, use of these compounds in medicine for treating diabetes (TGR5 modulators) and the intermediates involved in their preparation.

  本发明涉及一般式I的化合物及其药学上可接受的盐、药学上可接受的溶剂化合物、对映体、非对映体、前药、它们的N-氧化物、代谢物、多型体，在医学上用于治疗糖尿病（TGR5调节剂）以及其制备中涉及的中间体。
• INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME
  申请人：University Health Network (UHN)

  公开号：EP2766352A1

  公开（公告）日：2014-08-20