1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-4-((3-(trifluoromethyl)pyrrolidin-1-yl)methyl)-1H-pyrazole-3-carboxamide | 1429241-53-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-4-((3-(trifluoromethyl)pyrrolidin-1-yl)methyl)-1H-pyrazole-3-carboxamide
• 英文别名: 1-(2,4-dichlorophenyl)-N-piperidin-1-yl-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]thiophen-2-yl]-4-[[3-(trifluoromethyl)pyrrolidin-1-yl]methyl]pyrazole-3-carboxamide
• CAS: 1429241-53-1
• 化学式: C₃₄H₂₉Cl₂F₆N₅OS
• 分子量: 740.6
• InChiKey: VQESIPDQJZHGCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  49
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  81.6
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• PYRAZOLE COMPOUNDS
  申请人：Shia Kak-Shan

  公开号：US20130085126A1

  公开（公告）日：2013-04-04

  Compounds of formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , and X are defined herein. Also disclosed are pharmaceutical compositions and methods related to use of these compounds.

  式（I）的化合物：其中R1、R2、R3、R4、R5和X在此处定义。还披露了与这些化合物的使用相关的药物组合物和方法。
• US8962845B2
  申请人：——

  公开号：US8962845B2

  公开（公告）日：2015-02-24
• [EN] PYRAZOLE COMPOUNDS<br/>[FR] COMPOSÉS DE PYRAZOLE
  申请人：NAT HEALTH RESEARCH INSTITUTES

  公开号：WO2013048989A2

  公开（公告）日：2013-04-04

  Disclosed are pyrazole compounds, encompassed by formula (I) shown in the Specification, useful for treating peripheral cannabinoid 1 receptor mediated disorders. Also disclosed are pharmaceutical compositions and methods related to use of these compounds.