3-(5-((1R,2S)-2-(2,2-difluoropropanamido)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propoxy)-1H-indazol-1-yl)-N-(tetrahydrofuran-3-yl)benzamide | 1196509-62-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(5-((1R,2S)-2-(2,2-difluoropropanamido)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propoxy)-1H-indazol-1-yl)-N-(tetrahydrofuran-3-yl)benzamide
• 英文别名: 3-[5-[(1R,2S)-2-(2,2-difluoropropanoylamino)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy]indazol-1-yl]-N-(oxolan-3-yl)benzamide
• CAS: 1196509-62-2
• 化学式: C₃₂H₃₂F₂N₄O₆
• 分子量: 606.6
• InChiKey: ZZWJKLGCDHYVMB-QMQODZDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Phenyl and Benzodioxinyl Substituted Indazoles Derivatives
  申请人：Berger Markus

  公开号：US20100087489A1

  公开（公告）日：2010-04-08

  A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments

  一种化学式为Ia的化合物：本发明涉及新型吲哚基衍生物，涉及包含这种衍生物的药物组合物，涉及制备这种新型衍生物的方法以及将这种衍生物用作药物的用途。
• PHENYL AND BENZODIOXINYL SUBSTITUTED INDAZOLES DERIVATIVES
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20150080434A1

  公开（公告）日：2015-03-19

  A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments

  一种式Ia的化合物：本发明涉及新型吲唑基衍生物，包括这种衍生物的制药组合物，制备这种新型衍生物的方法以及将这种衍生物用作药物的用途。
• Phenyl and benzodioxinyl substituted indazole derivatives
  申请人：Astrazeneca AB

  公开号：EP2620435A1

  公开（公告）日：2013-07-31

  A compound of formula Ia : The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments

  式 Ia 的化合物： 本发明涉及新型吲唑基衍生物、含有此类衍生物的药物组合物、制备此类新型衍生物的工艺以及此类衍生物作为药物的用途
• BENZODIOXINYL SUBSTITUTED INDAZOLE DERIVATIVES
  申请人：AstraZeneca AB

  公开号：EP2291369B1

  公开（公告）日：2015-11-04
• Phenyl and benzodioxinyl substituted indazoles derivatives
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：US20170081315A1

  公开（公告）日：2017-03-23

  A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments