N1-[3-(4-chlorophenyl)-1H-5-pyrazolyl]-2-(2-methyl-1,3-dioxo-2,3-dihydro-1H-4-isoindolyl)acetamide | 1189359-15-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N1-[3-(4-chlorophenyl)-1H-5-pyrazolyl]-2-(2-methyl-1,3-dioxo-2,3-dihydro-1H-4-isoindolyl)acetamide
• 英文别名: N-[5-(4-chlorophenyl)-1H-pyrazol-3-yl]-2-(2-methyl-1,3-dioxoisoindol-4-yl)acetamide
• CAS: 1189359-15-6
• 化学式: C₂₀H₁₅ClN₄O₃
• 分子量: 394.817
• InChiKey: OZZPMNNHJZQALF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PHTHALIMIDE DERIVATIVES AS TRPA1 MODULATORS<br/>[FR] DÉRIVÉS DE PHTALIMIDE EN TANT QUE MODULATEURS DE TRPA1
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2009118596A2

  公开（公告）日：2009-10-01

  The present invention provides TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPAl (Transient Receptor Potential subfamily A, member 1) modulators. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPAl.