4-{5-amino-3-[3-(2-imidazol-1-yl-ethoxy)-4,5-dimethoxy-phenylamino]-[1,2,4]triazol-1-yl}-benzonitrile | 700807-74-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-{5-amino-3-[3-(2-imidazol-1-yl-ethoxy)-4,5-dimethoxy-phenylamino]-[1,2,4]triazol-1-yl}-benzonitrile
• 英文别名: 4-[5-Amino-3-[3-(2-imidazol-1-ylethoxy)-4,5-dimethoxyanilino]-1,2,4-triazol-1-yl]benzonitrile
• CAS: 700807-74-5
• 化学式: C₂₂H₂₂N₈O₃
• 分子量: 446.468
• InChiKey: KMFBIDNNPKOPPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES
  申请人：Pierce C. Albert

  公开号：US20080014189A1

  公开（公告）日：2008-01-17

  The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及蛋白激酶抑制剂。该发明还提供了包含本发明化合物的药物组合物以及使用该组合物治疗各种疾病的方法。
• Method to accelerate biodegradation of aliphatic-aromatic co-polyesters by enzymatic treatment
  申请人：Nagarajan Vasantha

  公开号：US20050261465A1

  公开（公告）日：2005-11-24

  Provided is a method for accelerating the biodegradation of aliphatic-aromatic co-polyesters comprising greater than 60 mol percent aromatic acid, based on total diacid in the co-polyester. The method involves contacting at least one hydrolytic enzyme in aqueous solution to the co-polyester.

  本发明提供了一种加速脂肪族-芳香族共聚多酯生物降解的方法，根据共聚多酯中的二酸总量，该共聚多酯中芳香族酸的含量大于 60 摩尔%。该方法包括将水溶液中的至少一种水解酶与共聚酯接触。
• Method to enhance biodegradation of sulfonated aliphatic-aromatic co-polyesters by addition of a microbial consortium
  申请人：Bramucci Michael

  公开号：US20060177930A1

  公开（公告）日：2006-08-10

  A microbial consortium for the biodegradation of sulfonated aliphatic-aromatic co-polyesters having greater than 60 mol percent aromatic acid content based on the total acid content of the co-polyester, created by applying selective pressure. Methods to biodegrade sulfonated aliphatic-aromatic co-polyesters using microbial consortium SPDC-1 are provided.
• US6255451B1
  申请人：——

  公开号：US6255451B1

  公开（公告）日：2001-07-03
• US7053130B2
  申请人：——

  公开号：US7053130B2

  公开（公告）日：2006-05-30