2-(Trichloromethyl)-4-[3-(trifluoromethyl)phenyl]quinazoline | 1008132-69-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(Trichloromethyl)-4-[3-(trifluoromethyl)phenyl]quinazoline
• CAS: 1008132-69-1
• 化学式: C₁₆H₈Cl₃F₃N₂
• 分子量: 391.607
• InChiKey: XHPUVXUWCIHDEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-氯-2-三氯甲基喹唑啉 、 3-(三氟甲基)苯硼酸 在 palladium diacetate caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 150.0 ℃ 、150.0 kPa 条件下， 反应 2.0h， 以50%的产率得到2-(Trichloromethyl)-4-[3-(trifluoromethyl)phenyl]quinazoline
  参考文献：
  名称：

  Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines

  摘要：

  A series of original 4-aryl-substituted 2-trichloromethylquinazoline derivatives was synthesized using a microwave-assisted Suzuki-Miyaura cross-coupling approach. Antiplasmodial activity was evaluated on both chloroquino-resistant and -sensitive Plasmodium falciparum strains, and the selectivity indexes for THP1 and HepG2 human cells were also calculated, revealing their antiplasmodial potential. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.027

文献信息

• Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines
  作者：Pierre Verhaeghe、Nadine Azas、Monique Gasquet、Sébastien Hutter、Christophe Ducros、Michèle Laget、Sylvain Rault、Pascal Rathelot、Patrice Vanelle

  DOI：10.1016/j.bmcl.2007.10.027

  日期：2008.1

  A series of original 4-aryl-substituted 2-trichloromethylquinazoline derivatives was synthesized using a microwave-assisted Suzuki-Miyaura cross-coupling approach. Antiplasmodial activity was evaluated on both chloroquino-resistant and -sensitive Plasmodium falciparum strains, and the selectivity indexes for THP1 and HepG2 human cells were also calculated, revealing their antiplasmodial potential. (C) 2007 Elsevier Ltd. All rights reserved.