5-(2-Chlorophenyl)-3-methyl-7-nitro-1,3,4,5-tetrahydro-1,4-benzodiazepine-2-thione | 1028633-77-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 5-(2-Chlorophenyl)-3-methyl-7-nitro-1,3,4,5-tetrahydro-1,4-benzodiazepine-2-thione
• CAS: 1028633-77-3
• 化学式: C₁₆H₁₄ClN₃O₂S
• 分子量: 347.825
• InChiKey: GIJVFXLLTGATJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-(2-Chlorophenyl)-3-methyl-7-nitro-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one 在 劳森试剂 作用下， 以 四氢呋喃 为溶剂， 生成 5-(2-Chlorophenyl)-3-methyl-7-nitro-1,3,4,5-tetrahydro-1,4-benzodiazepine-2-thione
  参考文献：
  名称：

  Meclonazepam analogues as potential new antihelmintic agents

  摘要：

  New analogues of the potent antihelmintic meclonazepam were prepared and evaluated against Schistosoma mansoni. The biological data suggests substitution at positions 2 and 4 of meclonazepam could provide promising analogues for prophylactic and therapeutic activity against S. mansoni. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.077

文献信息

• Meclonazepam analogues as potential new antihelmintic agents
  作者：Aman Mahajan、Vipan Kumar、Nuha R.N. Mansour、Quentin Bickle、Kelly Chibale

  DOI：10.1016/j.bmcl.2008.02.077

  日期：2008.4

  New analogues of the potent antihelmintic meclonazepam were prepared and evaluated against Schistosoma mansoni. The biological data suggests substitution at positions 2 and 4 of meclonazepam could provide promising analogues for prophylactic and therapeutic activity against S. mansoni. (C) 2008 Elsevier Ltd. All rights reserved.