6-chloro-2-phenyl-5-[4-(trifluoromethyl)anilino]-1H-benzimidazole-4,7-dione | 1034773-54-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-chloro-2-phenyl-5-[4-(trifluoromethyl)anilino]-1H-benzimidazole-4,7-dione
• CAS: 1034773-54-0
• 化学式: C₂₀H₁₁ClF₃N₃O₂
• 分子量: 417.774
• InChiKey: MESDJIBQFIVWFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  对三氟甲基苯胺 、 5,6-dichloro-2-phenyl-1H-benzo[d]imidazole-4,7-dione 以 乙醇 为溶剂， 反应 5.0h， 生成 6-chloro-2-phenyl-5-[4-(trifluoromethyl)anilino]-1H-benzimidazole-4,7-dione
  参考文献：
  名称：

  Design, synthesis and evaluation of 2-phenyl-1H-benzo[d]imidazole-4,7-diones as vascular smooth muscle cell proliferation inhibitors

  摘要：

  A series of 2-phenyl-1H-benzo[d]imidazole-4,7-diones were synthesized and tested for their inhibitory activity on the PDGF-stimulated proliferation of rat aortic vascular smooth muscle cells. Among the tested compounds, 6-arylthio-5-chloro-2-phenyl-1H-benzo[d]imidazole-4,7-diones exhibited an potent antiproliferative activity. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.03.066

文献信息

• Design, synthesis and evaluation of 2-phenyl-1H-benzo[d]imidazole-4,7-diones as vascular smooth muscle cell proliferation inhibitors
  作者：Chung-Kyu Ryu、Ra-Young Lee、Seung-Yon Lee、Hwa-Jin Chung、Sang Kook Lee、Kwang-Hoe Chung

  DOI：10.1016/j.bmcl.2008.03.066

  日期：2008.5

  A series of 2-phenyl-1H-benzo[d]imidazole-4,7-diones were synthesized and tested for their inhibitory activity on the PDGF-stimulated proliferation of rat aortic vascular smooth muscle cells. Among the tested compounds, 6-arylthio-5-chloro-2-phenyl-1H-benzo[d]imidazole-4,7-diones exhibited an potent antiproliferative activity. (C) 2008 Elsevier Ltd. All rights reserved.