ethyl 3-[(2S,3S,4S,5S)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxypyrrolidin-2-yl]propanoate | 948897-81-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 3-[(2S,3S,4S,5S)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxypyrrolidin-2-yl]propanoate
• CAS: 948897-81-2
• 化学式: C₁₁H₂₁NO₆
• 分子量: 263.291
• InChiKey: DANNJLBSVHIXCT-MXDNDHKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  119
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-((2S,3S,4S,5S)-5-((S)-1,2-bis(benzyloxy)ethyl)-3,4-bis(benzyloxy)pyrrolidin-2-yl)propionic acid ethyl ester 在 三氯化硼 、 Dowex 1X₈ 作用下， 以 正己烷 、 二氯甲烷 、 水 为溶剂， 反应 15.0h， 以51%的产率得到3-[(2S,3S,4S,5S)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxypyrrolidin-2-yl]propanoic acid
  参考文献：
  名称：

  Stereoselective synthesis of β-1-C-substituted 1,4-dideoxy-1,4-imino-d-galactitols and evaluation as UDP-galactopyranose mutase inhibitors

  摘要：

  The synthesis of 1-C-substituted 1,4-dideoxy-1,4-imino-D-galactitols involving nitrone umpolung is described. The SmI2-induced key coupling proved highly stereoselective in favor of the beta-C-substituted products bearing a three-carbon chain at the pseudoanomeric position. Pyrrolidines 9 and 10, as well as the bicyclic compounds 8 and 11, exhibit weak inhibition of the activity of the UDP-galactopyranose mutase from Escherichia coli. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.06.059

文献信息

• Stereoselective synthesis of β-1-C-substituted 1,4-dideoxy-1,4-imino-d-galactitols and evaluation as UDP-galactopyranose mutase inhibitors
  作者：Stéphanie Desvergnes、Valérie Desvergnes、Olivier R. Martin、Kenji Itoh、Hung-wen Liu、Sandrine Py

  DOI：10.1016/j.bmc.2007.06.059

  日期：2007.10

  The synthesis of 1-C-substituted 1,4-dideoxy-1,4-imino-D-galactitols involving nitrone umpolung is described. The SmI2-induced key coupling proved highly stereoselective in favor of the beta-C-substituted products bearing a three-carbon chain at the pseudoanomeric position. Pyrrolidines 9 and 10, as well as the bicyclic compounds 8 and 11, exhibit weak inhibition of the activity of the UDP-galactopyranose mutase from Escherichia coli. (C) 2007 Elsevier Ltd. All rights reserved.