(R)-2'-((5R,8S)-8-isopropyl-12,12-dimethyl-3,7,10-trioxo-5-vinyl-6,11-dioxa-2,9-diazatridecyl)-4-methyl-4,5-dihydro-[2,4'-bithiazole]-4-carboxylic acid | 1056880-61-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-2'-((5R,8S)-8-isopropyl-12,12-dimethyl-3,7,10-trioxo-5-vinyl-6,11-dioxa-2,9-diazatridecyl)-4-methyl-4,5-dihydro-[2,4'-bithiazole]-4-carboxylic acid
• CAS: 1056880-61-5
• 化学式: C₂₄H₃₄N₄O₇S₂
• 分子量: 554.689
• InChiKey: QEKXEYFMNIRWNS-AXMJJZENSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.13
• 重原子数：
  37.0
• 可旋转键数：
  11.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  156.28
• 氢给体数：
  3.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  (R)-2'-((5R,8S)-8-isopropyl-12,12-dimethyl-3,7,10-trioxo-5-vinyl-6,11-dioxa-2,9-diazatridecyl)-4-methyl-4,5-dihydro-[2,4'-bithiazole]-4-carboxylic acid 、 三氟乙酸 以 二氯甲烷 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Synthesis and Activity of Largazole Analogues with Linker and Macrocycle Modification

  摘要：

  To characterize largazole's structural requirements for histone deacetylase (HDAC) inhibitory and anti proliferative activities, a series of analogues with modifications to the side chain or 16-membered macrocycle were prepared and biologically evaluated. Structure-activity relationships suggested that the four-atom linker between the macrocycle and octanoyl group in the side chain and the (S)-configuration at the C17 position are critical to repression of HDAC activity. However, the valine residue in the macrocycle can be replaced with alanine without significant loss of activity.

  DOI：

  10.1021/ol801532s
• 作为产物：
  描述：

  methyl (R)-2'-((5R,8S)-8-isopropyl-12,12-dimethyl-3,7,10-trioxo-5-vinyl-6,11-dioxa-2,9-diazatridecyl)-4-methyl-4,5-dihydro-[2,4'-bithiazole]-4-carboxylate 在 lithium hydroxide 、 potassium hydrogensulfate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 2.0h， 生成 (R)-2'-((5R,8S)-8-isopropyl-12,12-dimethyl-3,7,10-trioxo-5-vinyl-6,11-dioxa-2,9-diazatridecyl)-4-methyl-4,5-dihydro-[2,4'-bithiazole]-4-carboxylic acid
  参考文献：
  名称：

  Synthesis and Activity of Largazole Analogues with Linker and Macrocycle Modification

  摘要：

  To characterize largazole's structural requirements for histone deacetylase (HDAC) inhibitory and anti proliferative activities, a series of analogues with modifications to the side chain or 16-membered macrocycle were prepared and biologically evaluated. Structure-activity relationships suggested that the four-atom linker between the macrocycle and octanoyl group in the side chain and the (S)-configuration at the C17 position are critical to repression of HDAC activity. However, the valine residue in the macrocycle can be replaced with alanine without significant loss of activity.

  DOI：

  10.1021/ol801532s