(5-Amino-2,3-dihydroindol-1-yl)-[3,5-bis(trifluoromethyl)phenyl]methanone | 890415-83-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (5-Amino-2,3-dihydroindol-1-yl)-[3,5-bis(trifluoromethyl)phenyl]methanone
• CAS: 890415-83-5
• 化学式: C₁₇H₁₂F₆N₂O
• 分子量: 374.285
• InChiKey: AVQYKSDFDIDOJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  [3,5-Bis(trifluoromethyl)phenyl]-(5-nitro-2,3-dihydroindol-1-yl)methanone 在 palladium on activated charcoal 氢气 作用下， 生成 (5-Amino-2,3-dihydroindol-1-yl)-[3,5-bis(trifluoromethyl)phenyl]methanone
  参考文献：
  名称：

  Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors

  摘要：

  Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs). (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.02.021

文献信息

• Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors
  作者：Hiroko Sano、Tomomi Noguchi、Atsushi Miyajima、Yuichi Hashimoto、Hiroyuki Miyachi

  DOI：10.1016/j.bmcl.2006.02.021

  日期：2006.6

  Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs). (c) 2006 Elsevier Ltd. All rights reserved.