5-(2,4-difluorobenzylidene)-3-ethyl-2-((2-fluoro-4-morpholinophenyl)imino)thiazolidin-4-one | 1313809-85-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 5-(2,4-difluorobenzylidene)-3-ethyl-2-((2-fluoro-4-morpholinophenyl)imino)thiazolidin-4-one
• CAS: 1313809-85-6
• 化学式: C₂₂H₂₀F₃N₃O₂S
• 分子量: 447.481
• InChiKey: KBFHUBFDYSNOQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.56
• 重原子数：
  31.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  45.14
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2-氟-4-(4-吗啉)苯胺 在 1-butyl-3-methylimidazolium hydroxide 作用下， 以 乙醇 为溶剂， 反应 9.0h， 生成 5-(2,4-difluorobenzylidene)-3-ethyl-2-((2-fluoro-4-morpholinophenyl)imino)thiazolidin-4-one
  参考文献：
  名称：

  Synthesis of 5-benzylidene-3-(3-fluoro-4-yl-morpholin-4-yl-phenylimino)-thiazolidin-4-one derivatives catalyzed by [BmIm]OH and their anti-microbial activity

  摘要：

  A series of novel 5-benzylidene-3-(3-fluoro-4-yl-morpholin-4-yl-phenylimino)thiazolidin-4-one derivatives were synthesized using [bmIm]OH as a catalyst and were tested for their antibacterial and antifungal activities. These compounds showed moderate in vitro activities against the microorganisms tested. (C) 2011 Sudhakar G. Patil. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2011.03.002