3-(3-Cyclopentyloxy-4-methoxyphenyl)-1,3-dihydroindol-2-one | 203002-21-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(3-Cyclopentyloxy-4-methoxyphenyl)-1,3-dihydroindol-2-one
• CAS: 203002-21-5
• 化学式: C₂₀H₂₁NO₃
• 分子量: 323.392
• InChiKey: TZXDUVYWNXDILB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(3-Cyclopentyloxy-4-methoxyphenyl)-1,3-dihydroindol-2-one 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Tert-butyl 3-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-3-(pyridin-4-ylmethyl)indole-1-carboxylate
  参考文献：
  名称：

  Quaternary substituted PDE4 inhibitors I: The synthesis and in vitro evaluation of a novel series of oxindoles

  摘要：

  The following letter presents the synthesis and in vitro evaluation of a novel quaternary substituted series of phosphodiesterase type (IV) (PDE4) inhibitors. The compounds represent conformationally constrained analogues of the Celltech PDE IV inhibitor, CDP 840. Examples with sub-micromolar IC50's for PDE4 inhibition are reported. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(97)10206-2
• 作为产物：
  描述：

  3-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-hydroxy-1,3-dihydro-indol-2-one 在 三乙基硅烷 、 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以53%的产率得到3-(3-Cyclopentyloxy-4-methoxyphenyl)-1,3-dihydroindol-2-one
  参考文献：
  名称：

  Quaternary substituted PDE4 inhibitors I: The synthesis and in vitro evaluation of a novel series of oxindoles

  摘要：

  The following letter presents the synthesis and in vitro evaluation of a novel quaternary substituted series of phosphodiesterase type (IV) (PDE4) inhibitors. The compounds represent conformationally constrained analogues of the Celltech PDE IV inhibitor, CDP 840. Examples with sub-micromolar IC50's for PDE4 inhibition are reported. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(97)10206-2

文献信息

• Quaternary substituted PDE4 inhibitors I: The synthesis and in vitro evaluation of a novel series of oxindoles
  作者：Christopher Hulme、Gregory B. Poli、Fu-Chih Huang、John E. Souness、Stevan W. Djuric

  DOI：10.1016/s0960-894x(97)10206-2

  日期：1998.1

  The following letter presents the synthesis and in vitro evaluation of a novel quaternary substituted series of phosphodiesterase type (IV) (PDE4) inhibitors. The compounds represent conformationally constrained analogues of the Celltech PDE IV inhibitor, CDP 840. Examples with sub-micromolar IC50's for PDE4 inhibition are reported. (C) 1998 Elsevier Science Ltd. All rights reserved.