3,8,13,18,23-pentaoxaheptacosanoic acid | 143429-35-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,8,13,18,23-pentaoxaheptacosanoic acid
• 英文别名: 2-[4-[4-[4-(4-Butoxybutoxy)butoxy]butoxy]butoxy]acetic acid
• CAS: 143429-35-0
• 化学式: C₂₂H₄₄O₇
• 分子量: 420.587
• InChiKey: TZIRONKSENPGDV-UHFFFAOYSA-N

物化性质

• 沸点：
  519.3±50.0 °C(Predicted)
• 密度：
  1.005±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  29
• 可旋转键数：
  25
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  83.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5,10-dioxa-tetradecane-1,14-diol 在 sodium hydride 作用下， 以 1,4-二氧六环 为溶剂， 反应 18.5h， 生成 3,8,13,18,23-pentaoxaheptacosanoic acid
  参考文献：
  名称：

  Artificial non-peptide single ion channels

  摘要：

  We report the synthesis of amphiphilic molecules composed of glycolate ethers of monoalkyloligo(1,4-butylene glycol) complexed with dioctadecyldimethylammonium cation. When inserted into a bilayer lipid membrane, these molecules exhibited several properties characteristic of single ion channels. Stable and constant conductance levels were observed, with transitions between open and closed states at a millisecond to second range. The conductance levels were on the order of 10(1)-10(3) pS, and the channels were classified into three types on the basis of their conductances and gating properties. The channels were cation selective over anion by a factor of approximately 5. In channels having the largest conductance, reversible and repeatable inactivation occurred with transmembrane voltages greater than 70 mV, while the other types of channels did not show voltage-dependent gating. We tentatively interpret these single ion channel properties to result from the formation of a molecular aggregate wherein the polar oligoether-carboxylates are covered with the hydrophobic alkyl groups of the ammonium in the bilayer membrane.

  DOI：

  10.1021/ja00046a002