Z-L-Iva-L-ATANP(Boc)2-(L-Iva)2-OMe | 328402-29-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-L-Iva-L-ATANP(Boc)2-(L-Iva)2-OMe
• CAS: 328402-29-5
• 化学式: C₄₃H₇₁N₇O₁₁
• 分子量: 862.077
• InChiKey: MTSBPVPHMPBPKE-XHDDDBEVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  61.0
• 可旋转键数：
  15.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  214.25
• 氢给体数：
  4.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  Z-L-Iva-L-ATANP(Boc)2-(L-Iva)2-OMe 在 N-羟基-7-氮杂苯并三氮唑 、 氢气 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 生成 Z-(L-Iva)2-L-ATANP(Boc)2-(L-Iva)2-OMe
  参考文献：
  名称：

  The First Water-Soluble 310-Helical Peptides

  摘要：

  Two water-soluble 3(10)-helical peptides are synthesized and fully characterized for the first time. The sequence of these terminally blocked heptamers comprises two residues of the Calpha-trisubstituted alpha-amino acid 2-amino-3-[1-(1,4,7-triazacyclononyl)]propanoic acid and five residues of a Calpha-tetrasubstituted alpha-amino acid (either alpha-aminoisobutyric acid or isovaline). Using CD and NMR techniques we were able to show that both heptapeptides are well structured in water, and that the type of conformation adopted is indeed the ternary 3(10)-helix.

  DOI：

  10.1002/1521-3765(20001215)6:24<4498::aid-chem4498>3.0.co;2-4
• 作为产物：
  描述：

  Z-L-ATANP(Boc)2-OH 在 N-羟基-7-氮杂苯并三氮唑 、 氢气 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 生成 Z-L-Iva-L-ATANP(Boc)2-(L-Iva)2-OMe
  参考文献：
  名称：

  The First Water-Soluble 310-Helical Peptides

  摘要：

  Two water-soluble 3(10)-helical peptides are synthesized and fully characterized for the first time. The sequence of these terminally blocked heptamers comprises two residues of the Calpha-trisubstituted alpha-amino acid 2-amino-3-[1-(1,4,7-triazacyclononyl)]propanoic acid and five residues of a Calpha-tetrasubstituted alpha-amino acid (either alpha-aminoisobutyric acid or isovaline). Using CD and NMR techniques we were able to show that both heptapeptides are well structured in water, and that the type of conformation adopted is indeed the ternary 3(10)-helix.

  DOI：

  10.1002/1521-3765(20001215)6:24<4498::aid-chem4498>3.0.co;2-4