But-2-ynoic acid (benzylcarbamoyl-furan-2-yl-methyl)-tert-butyl-amide | 440121-41-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: But-2-ynoic acid (benzylcarbamoyl-furan-2-yl-methyl)-tert-butyl-amide
• CAS: 440121-41-5
• 化学式: C₂₁H₂₄N₂O₃
• 分子量: 352.433
• InChiKey: ONBKDJABGDYJJR-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  But-2-ynoic acid (benzylcarbamoyl-furan-2-yl-methyl)-tert-butyl-amide 在 ytterbium(III) triflate 作用下， 以 1,4-二氧六环 为溶剂， 以81%的产率得到N-benzyl-2-tert-butyl-5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamide
  参考文献：
  名称：

  Studies on the sequential multi-component coupling/Diels–Alder cycloaddition reaction

  摘要：

  The synthesis of highly functionalized oxabicyclo[2.2.1]heptadiene derivatives through the sequential Use of all Ugi or Passerini multi-component coupling reaction followed by an intramolecular acetylene/furan Diels-Alder reaction was investigated. The nature of the heteroatom in the tether was determined to play a critical role. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02299-7
• 作为产物：
  描述：

  糠醛 、 2-丁炔酸 、 苄异腈 、 叔丁胺 以 甲醇 为溶剂， 以92%的产率得到But-2-ynoic acid (benzylcarbamoyl-furan-2-yl-methyl)-tert-butyl-amide
  参考文献：
  名称：

  Studies on the sequential multi-component coupling/Diels–Alder cycloaddition reaction

  摘要：

  The synthesis of highly functionalized oxabicyclo[2.2.1]heptadiene derivatives through the sequential Use of all Ugi or Passerini multi-component coupling reaction followed by an intramolecular acetylene/furan Diels-Alder reaction was investigated. The nature of the heteroatom in the tether was determined to play a critical role. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02299-7