3-Phosphoadenosine 5'-phosphate | 75431-54-8

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 3-Phosphoadenosine 5'-phosphate
• 英文别名: [6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-4H-purin-3-yl]phosphonic acid
• CAS: 75431-54-8
• 化学式: C₁₀H₁₇N₅O₁₀P₂
• 分子量: 429.22
• InChiKey: XVGAAHGKQIVCHH-AFPKLJJXSA-N

物化性质

• 溶解度：
  PBS（pH 7.2）：10 mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  -6.4
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  231
• 氢给体数：
  7
• 氢受体数：
  13

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S27,S36
• 危险类别码：
  R36/37/38

文献信息

• METHOD FOR INCREASING PLANT STRESS TOLERANCE AND SEED DORMANCY
  申请人：The Australian National University

  公开号：EP3317408A1

  公开（公告）日：2018-05-09
• Process for chromosomal expression of foreign genes in the PAPS reductase (cysH) region of a methylotrophic microbial host cell
  申请人：Dicosimo J. Deana

  公开号：US20070065901A1

  公开（公告）日：2007-03-22

  Provided is a method for stably expressing an introduced gene or genes in a methylotrophic microorganism host wherein the gene(s) are integrated into the cysH region of the chromosome. This method provides stable, high-level expression of the integrated genes in which growth rate and/or viability of the host strain is not significantly affected and a selection marker is not required. The use of this method for expressing carotenoid biosynthetic genes and resulting production of carotenoids is also described.
• [EN] SULFOTRANSFERASE ASSAY<br/>[FR] ESSAI DE SULFOTRANSFÉRASE
  申请人：RES AND DIAGNOSTIC SYSTEMS INC

  公开号：WO2012161688A1

  公开（公告）日：2012-11-29

  Assays and methods for detecting and/or quantifying activity of a test sulfotransferase comprising by releasing a free phosphate from the PAP produced by the sulfotransferase reaction and detecting the free phosphate. The assay can includes gPAPP, a free phosphate detector and an optional control sulfotransferase. The method includes combining a test sulfotransferase with the substrate of the sulfotransferase, PAPS and gPAPP and detecting the free phosphate. The level of free phosphate directly correlates to the activity of the sulfotransferase. The assay and methods can be used to screen agents for their effect upon sulfotransferase activity.
• [EN] METHOD FOR INCREASING PLANT STRESS TOLERANCE AND SEED DORMANCY<br/>[FR] PROCÉDÉ PERMETTANT D'AUGMENTER LA TOLÉRANCE À LA CONTRAINTE DES PLANTES ET LA DORMANCE D'UNE GRAINE
  申请人：THE AUSTRALIAN NAT UNIV

  公开号：WO2017000018A1

  公开（公告）日：2017-01-05

  The present invention provides a method for increasing the levels of 3'- phosphoadenosine-5 '-phosphate (PAP) or a derivative or analogue thereof in cells of said plant compared to an untreated or wild- type plant grown under the same stress conditions. The methods may comprise administration to the plant and/or the soil it is growing in of: PAP or a derivative or analogue thereof; a substance that enhances or promotes synthesis or accumulation of PAP or said derivative or analogue thereof; or a substance that inhibits or compromises an activity metabolising or removing PAP or said derivative or analogue thereof. Alternatively, the methods may comprise genetic modification of cells of said plant which modifications allow for increased accumulation of PAP or a derivative or analogue thereof in cells of said plant (or in seeds thereof) at least under stress conditions compared to a wild-type plant. The methods find particular application in increasing the tolerance of plants to abiotic stress conditions, which may be selected from increased salinity, increased sodium levels, drought, light stress and pH stress. The present invention also provides a method for extending the dormancy of a seed, as compared to an untreated seed, said method comprising accumulating in cells within said seed an increased level of PAP or a derivative or analogue thereof compared to an untreated or wild-type seed.
• [EN] METHODS OF INHIBITING RNA PROOFREADING AND THERAPEUTIC APPLICATIONS THEREOF<br/>[FR] MÉTHODES D'INHIBITION DE CORRECTION D'ÉPREUVE D'ARN ET APPLICATIONS THÉRAPEUTIQUES ASSOCIÉES
  申请人：[en]SCHMIER, Brad

  公开号：WO2022119914A1

  公开（公告）日：2022-06-09

  The invention relates to the use of a combination of a lithium composition with at least one inhibitor of an RNA-dependent RNA polymerase in the treatment of an RNA virus, wherein the RNA virus encodes a 3' to 5' exonuclease.