tris(acetoxymethyl)-acrylamidomethane | 155820-33-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tris(acetoxymethyl)-acrylamidomethane
• 英文别名: tris(acetoxymethyl)acrylamidomethane；[3-Acetyloxy-2-(acetyloxymethyl)-2-(prop-2-enoylamino)propyl] acetate
• CAS: 155820-33-0
• 化学式: C₁₃H₁₉NO₇
• 分子量: 301.296
• InChiKey: CBMKYWZVYSAVLU-UHFFFAOYSA-N

物化性质

• 沸点：
  458.4±45.0 °C(Predicted)
• 密度：
  1.183±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  tris(acetoxymethyl)-acrylamidomethane 在 甲醇 、 sodium methylate 、 三乙胺 作用下， 反应 2.5h， 生成 rac-3-[(7-N-(tris(hydroxymethyl)methyl)amino-4-thiapimeloyl)amino]propane-1,2-diyl bis(octadecylcarbamate)
  参考文献：
  名称：

  Exotic aqueous behavior of synthetic lipids: formation of vesicular nanotubes

  摘要：

  The work reported herein deals with the synthesis and the aggregation behavior studies of synthetic lipids bearing a nonionic polar head made up of a tris(hydroxymethyl) aminomethane (tris) moiety linked with an aminoglycerol interface. The hydrophobic chains with variable lengths were grafted onto the hydroxyl functions of the aminoglycerol residue through ester or carbarnate bonds. Tiny chemical modifications within this family of non-ionic surfactants brought about major variations in their aggregation behavior. They formed vesicles, tubules, and also small stable end-capped tubules - called vesicular nanotubes -, when the polar head bore two heptadecyl chains linked through a carbarnate bond. Various techniques (nanosizer measurements, freeze fracture electron microscopy (FFEM), transmission electron microscopy (TEM), carboxyfluorescein (CF)) encapsulation were used to specify the structure of these assemblies. Notably, the vesicular nanotubes exhibited a small size, a fair polydispersity, great stability in an aqueous solution (up to 1 year) and a good efficiency to entrap and slowly release a probe such as carboxyfluoresceine: all these properties are perfectly suitable for their use as potential drug carriers. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

  DOI：

  10.1016/j.chemphyslip.2005.03.006
• 作为产物：
  描述：

  N-三羟甲基甲基丙烯酰胺 、 乙酸酐 在 吡啶 作用下， 反应 12.0h， 以87%的产率得到tris(acetoxymethyl)-acrylamidomethane
  参考文献：
  名称：

  带有RGD的生物相容性端粒的合成和初步生物学评估。

  摘要：

  本文报道的工作涉及一类新的生物相容性端粒载体的合成和初步生物学评估，所述载体具有作为肿瘤细胞靶向的肽RGDSK序列和以125I标记的酪氨酸部分作为体内探针。将这些端粒静脉注射到带有嫁接的B16同基因黑素瘤的小鼠体内后，在几个组织中获得的放射性水平表明，在端粒结构中添加RGD残基后，其对肿瘤周围高度血管化区域的亲和力增加。

  DOI：

  10.1016/s0960-894x(02)00079-3

文献信息

• Influence des interactions protiques sur les cinétiques de polymérisation du tris(hydroxyméthyl)acrylamidométhane (THAM) et de ses dérivés
  作者：Fabrice Giusti、Sabine Mansis、Bernard Pucci

  DOI：10.1039/b206463d

  日期：——

  solvant. Dans le but de vérifier ces hypothèses, différents monomères dérivés du THAM N- ou O-substitués ont été synthétisés et leurs constantes cinétiques de polymérisation ont été précisées. La réactivité du monomère évolue bien en fonction du nombre de fonctions alcool disponibles sur le monomère ainsi qu'en fonction de la taille des substituants utilisés pour protéger les fonctions hydroxyle. La liaison

  乐 三（羟甲基）丙烯酰胺基丁烷 （THAM）永久性多边贸易协定类型的平均水平 丙烯酰胺分类。假若发生伪善现象的话，易化解的单身人士将被解散或重新获得单一或集体抚养人的权利。daccess-ods.un.org daccess-ods.un.org daccess-ods.un.org daccess-ods.un.org daccess-ods.un.org daccess-ods.un.org daccess-ods.un.org 加强和加强联络人的单身或多人联络的权利。担保人的假说，在THAM N -ou O上替代了不同的垄断者，并在法律上统一了法律和法律的统一性。daccess-ods.un.org daccess-ods.un.org daccess-ods.un.org daccess-ods.un.org daccess-ods.un.org 禁止在全国范围内使用单品和单价的替
• Noval Surfactants and Applications Thereof
  申请人：Pucci Bernard

  公开号：US20070275046A1

  公开（公告）日：2007-11-29

  The invention relates to novel surfactant compounds and the use thereof for preparing metastable supramolecular systems or nanoparticles. Said nanoparticles may be used as vectors for active ingredients, in particular therapeutic active ingredients.

  该发明涉及新型表面活性剂化合物及其用于制备亚稳态超分子系统或纳米粒子的用途。所述纳米粒子可用作活性成分的载体，特别是治疗活性成分。
• Process of extraction of a platinum group metal or gold from organic compositions with surfactants
  申请人：Centre National de la Recherche Scientifique

  公开号：US10752976B2

  公开（公告）日：2020-08-25

  The present invention is in the field of surfactants to extract a platinum group metal or gold, in particular palladium, from organic compositions. In particular, the invention concerns the use of surfactants to back-extract a platinum group metal or gold, in particular palladium, from organic compositions further comprising an extractant of said platinum group metal or gold, in particular palladium from an aqueous solution.

  本发明属于表面活性剂领域，用于从有机组合物中萃取铂族金属或金，特别是钯。特别是，本发明涉及使用表面活性剂从有机组合物中反萃取铂族金属或金，特别是钯，进一步包括从水溶液中萃取所述铂族金属或金，特别是钯的萃取剂。
• In vitro and in vivo evaluations of THAM derived telomers bearing RGD and Ara-C for tumour neovasculature targeting
  作者：S. Jasseron、C. Contino-Pépin、J.C. Maurizis、M. Rapp、B. Pucci

  DOI：10.1016/s0223-5234(03)00150-8

  日期：2003.9

  As an approach to the development of specific drug delivery systems, a new class of low macromolecular carriers called 'telomers' endowed with an antitumour agent, such as arabinofuranosylcytosine (Ara-C), RGDSK peptidic sequences, as tumour targeting moieties, and tyrosine groups labelled with I-125 atoms allowing the in vivo scintigraphic follow up, were synthesized. Their tumour targeting ability was assessed in vivo in mice bearing a murine B16 melanoma. The biological results showed that the presence of RGDSK sequences onto the macromolecules leads to the selective targeting and the accumulation of telomers within the vascularized zone of the tumour. Moreover, such compounds exhibited in vitro a better IC50 (0.015 muM) than pure Ara-C and in vivo an oncostatic index higher than 160%. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
• NOUVEAUX TENSIO-ACTIFS ET LEURS APPLICATIONS
  申请人：TS Pharma

  公开号：EP1708993A2

  公开（公告）日：2006-10-11