3-[2-(3-fluorophenyl)-2H-pyrazol-3-yl]-1-isoquinolin-6-yl-1H-pyridazin-4-one | 1240649-07-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[2-(3-fluorophenyl)-2H-pyrazol-3-yl]-1-isoquinolin-6-yl-1H-pyridazin-4-one
• 英文别名: 3-[2-(3-Fluorophenyl)pyrazol-3-yl]-1-isoquinolin-6-ylpyridazin-4-one
• CAS: 1240649-07-3
• 化学式: C₂₂H₁₄FN₅O
• 分子量: 383.384
• InChiKey: RQELHESIVZBDCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• HETEROARYL SUBSTITUTED PYRIDAZINONE DERIVATIVES
  申请人：Alberati Daniela

  公开号：US20100216793A1

  公开（公告）日：2010-08-26

  The present invention is concerned with novel pyridazinone derivatives of formula (I) wherein R 1 , R 2 , R 3 and R 4 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as pharmaceuticals.

  本发明涉及具有如下式（I）的新型吡啶并嗪酮衍生物，其中R1、R2、R3和R4如描述和索赔中所定义，并且其生理上可接受的盐和酯。这些化合物抑制PDE10A并可用作药物。
• US9187455B2
  申请人：——

  公开号：US9187455B2

  公开（公告）日：2015-11-17
• [EN] HETEROARYL SUBSTITUTED PYRIDAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE PYRIDAZONE À SUBSTITUTION HÉTÉROARYLE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2010094762A1

  公开（公告）日：2010-08-26

  The present invention is concerned with novel pyridazinone derivatives of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as medicaments.