3-甲基噻嘧啶柠檬酸盐 | 69525-81-1

• 物质功能分类: 医药中间体 - 杂环化合物 - 嘧啶类化合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-甲基噻嘧啶柠檬酸盐
• 中文别名: 1,4,5,6-四氢-1-甲基-2-(2-[3-甲基-2-噻吩基]乙烯基)嘧啶；3-甲基噻嘧啶；莫它太尔柠檬酸；柠檬酸甲噻嘧啶
• 英文名称: 2-(carboxymethyl)-2-hydroxybutanedioate;1-methyl-2-[(E)-2-(3-methylthiophen-2-yl)ethenyl]-1,4,5,6-tetrahydropyrimidine-1,3-diium
• CAS: 69525-81-1
• 化学式: C18H24N2O7S
• 分子量: 412.5
• InChiKey: OLOCXIJVDIVAHH-FXRZFVDSSA-N

物化性质

• 熔点：
  114-116°C
• 溶解度：
  在水中的溶解度为4.0ML，澄清，黄绿色(200mg+4.0mLH2O)
• 碰撞截面：
  150.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
• 稳定性/保质期：
  远离氧化物、光和热。

计算性质

• 辛醇/水分配系数(LogP)：
  1.56
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  176
• 氢给体数：
  4
• 氢受体数：
  9

安全信息

• 危险品标志：
  Xn
• 海关编码：
  2934999090

文献信息

• Laminate device for controlled and prolonged release of substances to an ambient environment
  申请人：PFIZER INC.

  公开号：EP0153070A2

  公开（公告）日：1985-08-28

  Laminate device for the controlled and prolonged release of at least one active agent to an ambient environment comprising at least one core sheet, said core sheet or sheets comprising said agent or agents in a polymer matrix, and, in a preferred embodiment, a porosity enhancing agent in admixture with said agent; said core sheet or sheets be:ng alternately sandwiched or interposed between coextensive inert polymeric films substantially impermeable to said environment and to said agent or agents, said device being perforated by one or a plurality of macroholes extending through said sheets and said films. In a modification of said device the perimeter edge thereof is coated by an inert polymeric film substantially impermeable to said environment and to said agent or agents. Also included are methods for making such a device.

  用于控制和延长向周围环境释放至少一种活性剂的层压装置，该装置包括至少一个芯片，所述芯片包括聚合物基质中的所述一种或多种制剂，在一个优选的实施方案中，还包括与所述制剂混合的孔隙度增强剂；所述芯片交替地夹在或插在基本上不渗透所述环境和所述一种或多种制剂的同层惰性聚合物薄膜之间：ng 交替夹在或插在惰性聚合薄膜之间，这些薄膜对环境和制剂具有很好的防渗透性，所述装置上有一个或多个大孔穿过所述薄片和薄膜。在所述装置的一种改型中，其周边边缘涂有一层惰性聚合薄膜，该薄膜对所述环境和所述一种或多种药剂基本上是不渗透的。还包括制造这种装置的方法。
• Method for enhancing the unrolling of a rolled matrix device
  申请人：PFIZER INC.

  公开号：EP0334516A2

  公开（公告）日：1989-09-27

  A method for enhancing the unrolling of an active agent-containing matrix device, including a laminate device, in an aqueous use environment, said device being constrained in a rolled configuration prior to placement in said environment, comprising subjecting the device to an annealing step prior to constraining it in a rolled configuration; and the devices so treated.

  一种用于提高含活性剂基质装置（包括层压装置）在水性使用环境中的展开性能的方法，所述装置在放入所述环境之前被限制在轧制结构中，包括在将装置限制在轧制结构之前对其进行退火步骤；以及如此处理的装置。
• COMPOSITION FOR BEVERAGE OR FOOD
  申请人：Nippon Paper Chemicals Co., Ltd.

  公开号：EP2005841A1

  公开（公告）日：2008-12-24

  It is an object of the present invention to provide a composition for a food or beverage containing a butyric acid bacterium which produces butyric acid and is excellent in intestinal regulation and cellooligosaccharide which serves as a substrate for the butyric acid bacterium and facilitates the production of butyric acid, enhancing an amount of butyric acid produced in intestine and being excellent in functions to improve an enteric environment and protect against an infectious disease. That is, the present invention provides a composition for a food or beverage containing a butyric acid bacterium and cellooligosaccharide and having a function to improve an enteric environment and/or a function to protect against an infectious disease, a composition for a food or beverage wherein the butyric acid bacterium is Clostridium butyricum, a feedstuff containing a butyric acid bacterium and cellooligosaccharide and having a function to improve an enteric environment and/or a function to protect against an infectious disease, and a food containing a butyric acid bacterium and cellooligosaccharide and having a function to improve an enteric environment and/or a function to protect against an infectious disease.

  本发明的目的是提供一种用于食品或饮料的组合物，该组合物含有能产生丁酸并具有良好肠道调节功能的丁酸杆菌，以及作为丁酸杆菌底物并能促进丁酸产生的纤维寡糖，能提高肠道中丁酸的产生量，并具有良好的改善肠道环境和预防传染病的功能。也就是说，本发明提供了一种含有丁酸杆菌和纤维寡糖的食品或饮料组合物，具有改善肠道环境和/或预防传染病的功能，其中丁酸杆菌为丁酸梭菌、一种含有丁酸杆菌和纤维寡糖并具有改善肠道环境和/或防止传染病功能的饲料，以及一种含有丁酸杆菌和纤维寡糖并具有改善肠道环境和/或防止传染病功能的食品。
• GRANULES IN LIQUID DOSAGE FORM
  申请人：Idemitsu Kosan Co., Ltd

  公开号：EP2700407A1

  公开（公告）日：2014-02-26

  A formulation which comprises coated granules and a water-soluble gel, wherein the coated granules comprise an oil absorbent which comprises cashew nut shell liquid, anacardic acid, cardanol, or cardol, and wherein the coated granules are suspended in the water-soluble gel.

  一种制剂，包括包衣颗粒和水溶性凝胶，其中包衣颗粒包含一种吸油剂，该吸油剂由腰果壳液、无患子酸、棉子醇或棉子酚组成，包衣颗粒悬浮在水溶性凝胶中。
• Animal feed additives
  申请人：NISSHIN FEED INC.

  公开号：US20020039606A1

  公开（公告）日：2002-04-04

  The present invention relates to an animal feed additive, which comprises at least two components selected from the group consisting of the following three components (a), (b) and (c): (a) at least one herb selected from Pine Needle, Hawthorn Fruit, Bighead Atractylodes Rhizome, Milkvetch Root, Skullcap Root, Tangerine Fruit and Mint Siftings; (b) a live bacteria mixture composed of a yeast cell wall and a live bacteria preparation containing Lactobacillus acidophilus and/or Enterococcus faecium ; and (c) an organic acid.

  本发明涉及一种动物饲料添加剂，它包括至少两种从以下三种成分（a）、（b）和（c）组成的组中选出的成分： (a) 至少一种草药，选自松针、山楂果、大头白术根茎、黄芪根、毛莨根、橘子果和薄荷筛； (b) 活菌混合物，由酵母细胞壁和活菌制剂组成，活菌制剂含有 嗜酸乳杆菌 和/或 粪肠球菌 (c) 一种有机酸。