3-甲基氨基丙酸叔丁酯盐酸盐 | 866534-15-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-甲基氨基丙酸叔丁酯盐酸盐
• 英文名称: 3-methylaminopropionic acid tert-butyl ester hydrochloride
• 英文别名: N-methyl-β-alanine 1,1-dimethylethyl ester hydrochloride；H-beta-MeAla-OtBu*HCl；tert-butyl 3-(methylamino)propanoate;hydrochloride
• CAS: 866534-15-8
• 化学式: C₈H₁₇NO₂*ClH
• 分子量: 195.689
• InChiKey: MYTIVPYUPOXXCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.36
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  38.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-甲基氨基丙酸叔丁酯盐酸盐 在 5 % platinum on carbon 、 vanadia 噻吩 、 盐酸 、 氢气 、 magnesium sulfate 、 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 、 乙醇 、 异丙醚 、 N,N-二甲基乙酰胺 、 乙酸乙酯 、 乙腈 为溶剂， 20.0~80.0 ℃ 、101.33 kPa 条件下， 反应 15.0h， 生成 tert-butyl 3-[[3-[2-chloro-5-[[4-[2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]ethylamino]-6-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methylamino]phenoxy]-2-hydroxypropyl]-methylamino]propanoate
  参考文献：
  名称：

  WO2008/155421

  摘要：

  公开号：

文献信息

• [EN] PYRROLOPYRIMIDINES<br/>[FR] PYRROLOPYRIMIDINES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009016132A1

  公开（公告）日：2009-02-05

  The present invention relates to compounds or pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to compounds that are polo-like kinase (PLKs) inhibitors useful for the treatment of disease states mediated by PLK, especially PLK4, in particular such compounds that are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumour growth, rheumatoid arthritis, restenosis and atherosclerosis.

  本发明涉及化合物或其药用盐，制备它们的方法，含有它们的药物组合物以及它们在治疗中的用途。该发明特别涉及一类极化样激酶（PLKs）抑制剂化合物，用于治疗由PLK介导的疾病状态，特别是PLK4，特别是在治疗涉及异常细胞增殖的病理过程中有用的化合物，如肿瘤生长、类风湿性关节炎、再狭窄和动脉粥样硬化。
• [EN] SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT<br/>[FR] AGONISTES DES RÉCEPTEURS DE LA SPHINGOSINE-1-PHOSPHATE, LEURS PROCÉDÉS DE PRÉPARATION, ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT EN TANT QUE PRINCIPE ACTIF
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2014129796A1

  公开（公告）日：2014-08-28

  The present invention relates to novel compounds of Formula 1 as sphingosine-1-phosphate receptor agonists which can be effectively used for the treatment of autoimmune diseases, a method for preparing the same, and a pharmaceutical composition comprising the same as an active component. The compounds according to the present invention are effective on extensive autoimmune diseases and chronic inflammatory diseases including relapsing-remitting multiple sclerosis, and can also be used for treating or preventing immunoregulation disorders.

  本发明涉及一种新的化合物，其化学式为Formula 1，作为鞘氨醇-1-磷酸受体激动剂，可有效用于治疗自身免疫性疾病，以及一种制备该化合物的方法和包含该化合物作为活性成分的药物组合物。根据本发明的化合物对广泛的自身免疫性疾病和慢性炎症性疾病，包括复发-缓解型多发性硬化症等具有有效作用，并且还可用于治疗或预防免疫调节紊乱。
• Tetrahydronaphthyridine derivatives and a process for preparing the same
  申请人：Kubota Hitoshi

  公开号：US20070032485A1

  公开（公告）日：2007-02-08

  A novel compound of the formula (I): wherein R 1 is alkoxycarbonyl or the like, R 2 is alkyl or the like; R 3 is hydrogen or the like; R 4 is alkylene or the like; R 5 is optionally substituted heterocyclic group; R 6 , R 7 , and R 8 are independently hydrogen; alky, alkoxy, or the like; R 10 is optionally substituted aromatic ring, or the like; or a pharmaceutically acceptable salt thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP).

  一种化合物的公式（I）：其中R1为烷氧羰基或类似物，R2为烷基或类似物；R3为氢或类似物；R4为烷基或类似物；R5为可选取代的杂环基；R6、R7和R8分别为氢、烷基、烷氧基或类似物；R10为可选取代的芳香环或类似物；或其药学上可接受的盐，该化合物具有对胆固醇酯转移蛋白（CETP）的抑制活性。
• SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT
  申请人：LG LIFE SCIENCES LTD.

  公开号：US20150376173A1

  公开（公告）日：2015-12-31

  The present invention relates to novel compounds of Formula 1 as sphingosine-1-phosphate receptor agonists which can be effectively used for the treatment of autoimmune diseases, a method for preparing the same, and a pharmaceutical composition comprising the same as an active component. The compounds according to the present invention are effective on extensive autoimmune diseases and chronic inflammatory diseases including relapsing-remitting multiple sclerosis, and can also be used for treating or preventing immunoregulation disorders.

  本发明涉及一种新型化合物，其化学式为1，作为鞘氨醇-1-磷酸受体激动剂，可有效用于治疗自身免疫性疾病，以及制备该化合物的方法和包含该化合物作为活性成分的制药组合物。本发明的化合物对广泛的自身免疫性疾病和慢性炎症性疾病，包括复发缓解型多发性硬化症等具有疗效，并可用于治疗或预防免疫调节失调。
• [EN] TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS<br/>[FR] DERIVES DE TETRAHYDRONAPHTYRIDINE ET PROCEDE D'ELABORATION DESDITS DERIVES
  申请人：TANABE SEIYAKU CO

  公开号：WO2005095395A3

  公开（公告）日：2006-06-01