tert-butyl 4-[(5-carbamoyI-2-ethyl-2H-pyrazol-3-yl)methyl]-4-hydroxypiperidine-1-carboxylate | 912442-34-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl 4-[(5-carbamoyI-2-ethyl-2H-pyrazol-3-yl)methyl]-4-hydroxypiperidine-1-carboxylate
• 英文别名: Tert-butyl 4-[(5-carbamoyl-2-ethylpyrazol-3-yl)methyl]-4-hydroxypiperidine-1-carboxylate
• CAS: 912442-34-3
• 化学式: C₁₇H₂₈N₄O₄
• 分子量: 352.434
• InChiKey: DMAWOWSGTFRUQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• 1-Substituted Pyrazolo (3,4-C) Ring Compounds as Modulators of Cytokine Biosynthesis for the Treatment of Viral Infections and Neoplastic Diseases
  申请人：Hays David S.

  公开号：US20090163533A1

  公开（公告）日：2009-06-25

  Pyrazolo[3,4-c] ring compounds of Formula (I), e.g., pyrazolo[3,4-c]pyridines, pyrazolo[3,4-c]quinolines, 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinolines, and pyrazolo[3,4-c]naphthyridines, substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

  公开了化学式（I）的吡唑并[3,4-c]环化合物，例如吡唑并[3,4-c]吡啶、吡唑并[3,4-c]喹啉、6,7,8,9-四氢吡唑并[3,4-c]喹啉和吡唑并[3,4-c]萘啉，这些化合物在1位被取代，制备的中间体、含有这些化合物的药物组合物、制备方法以及这些化合物作为免疫调节剂的使用方法、用于诱导动物细胞因子生物合成和治疗包括病毒和肿瘤性疾病等疾病的方法。
• 1-SUBSTITUTED PYRAZOLO (3,4-C) RING COMPOUNDS AS MODULATORS OF CYTOKINE BIOSYNTHESIS FOR THE TREATMENT OF VIRAL INFECTIONS AND NEOPLASTIC DISEASES
  申请人：Coley Pharmaceutical Group, Inc.

  公开号：EP1863814A1

  公开（公告）日：2007-12-12
• US7943636B2
  申请人：——

  公开号：US7943636B2

  公开（公告）日：2011-05-17
• [EN] 1-SUBSTITUTED PYRAZOLO (3,4-C) RING COMPOUNDS AS MODULATORS OF CYTOKINE BIOSYNTHESIS FOR THE TREATMENT OF VIRAL INFECTIONS AND NEOPLASTIC DISEASES<br/>[FR] COMPOSES CYCLIQUES 1-PYRAZOLO[3,4-C] SUBSTITUES COMME MODULATEURS DE LA BIOSYNTHESE DE CYTOKINE DESTINES AU TRAITEMENT D'INFECTIONS VIRALES ET DE MALADIES NEOPLASTIQUES
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2006107851A1

  公开（公告）日：2006-10-12

  [EN] Pyrazolo[3,4-c] ring compounds of Formula (I), e.g., pyrazolo[3,4-c]pyridines, pyrazolo[3,4-c]quinolines, 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinolines, and pyrazolo[3,4-c]naphthyridines, substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
  [FR] L'invention concerne des composés cycliques pyrazolo[3,4-c] de la formule I, par exemple pyrazolo[3,4-c]pyridines, pyrazolo[3,4-c]quinoléines, 6,7,8,9-tétrahydro pyrazolo[3,4-c]quinoléines, et pyrazolo[3,4-c]naphtyridines, substituées en position 1, des compositions pharmaceutiques contenant ces composés, des intermédiaires, ainsi que des procédés de fabrication et d'utilisation des ces composés comme immunomodulateurs, pour induire la biosynthèse de cytokine chez les animaux et dans le traitement de maladies, notamment des maladies virales et néoplastiques.