2-[(E)-2-(3-(4-carboxy-4-methylvalerylamino)phenyl)ethenyl]-6-(4-cyclohexylbutoxy)methylpyridine | 140132-80-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-[(E)-2-(3-(4-carboxy-4-methylvalerylamino)phenyl)ethenyl]-6-(4-cyclohexylbutoxy)methylpyridine
• 英文别名: 5-[3-[(E)-2-[6-(4-cyclohexylbutoxymethyl)pyridin-2-yl]ethenyl]anilino]-2,2-dimethyl-5-oxopentanoic acid
• CAS: 140132-80-5
• 化学式: C₃₁H₄₂N₂O₄
• 分子量: 506.685
• InChiKey: MCJPSNIUJGLLCP-ISLYRVAYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  37
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  88.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Styryl compounds and their pharmaceutical use
  申请人：YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP0466125A2

  公开（公告）日：1992-01-15

  A styryl compound of the formula(I): wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt or an ester thereof is disclosed. Since the compounds of the present invention possess potent and long-lasting leukotriene-antagonistic actions and inhibitory actions against leukotriene, and exhibit better absorption by the oral administration. Further, the compounds of the present invention possess 5-lipoxygenase-inhibitoryactions and/or cyclooxygenase-inhibitory actions, inhibitory actions to biosynthesis of LTB4, chemotactic actions against human leucocyte, chymase-inhibitory actions, inhibiyory actions to release of histamine or anti-histamine actions. Therefore, they are useful as the prophylactic and therapeutic medicines for brochial asthma, chronic bronchitis, atopic dermatitis, allergic rhinitis, allergic arthritis, allergic conjunctivitis, hay fever, urticaria, alimentary allergy, pain, pyretolysis, rheumatoid, thrombosis, coronary vascular diseases, ischemic heart disease, peptic or duodenal ulcer and the like.

  本发明公开了一种式(I)的苯乙烯基化合物： 其中各符号如说明书中所定义，本发明公开了其药学上可接受的盐或酯。 由于本发明的化合物具有强效、持久的白三烯拮抗作用和白三烯抑制作用，并且口服吸收效果更好。 此外，本发明化合物还具有 5-脂氧合酶抑制作用和/或环氧合酶抑制作用、LTB4 生物合成抑制作用、对人类白细胞的趋化作用、糜蛋白酶抑制作用、组胺释放抑制作用或抗组胺作用。 因此，它们可作为预防和治疗药物，用于治疗哮喘、慢性支气管炎、特应性皮炎、过敏性鼻炎、过敏性关节炎、过敏性结膜炎、花粉热、荨麻疹、消化道过敏、疼痛、热解、类风湿、血栓形成、冠状血管疾病、缺血性心脏病、消化道或十二指肠溃疡等疾病。