2,2-dihydroxy-3-phenylpropionic acid | 55833-40-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2,2-dihydroxy-3-phenylpropionic acid
• 英文别名: dihydroxyphenyl-propionic acid；hydroxyphenyllactic acid；dihydroxydihydrocinnamic acid；2,2-Dihydroxy-3-phenylpropanoic acid
• CAS: 55833-40-4
• 化学式: C₉H₁₀O₄
• 分子量: 182.176
• InChiKey: XQKJQIUZEFAGFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] PROCESS FOR PREPARING TAXOL SIDE CHAIN USING HETEROGENEOUS TRIFUNCTIONAL CATALYST<br/>[FR] PROCEDE DE PREPARATION D'UNE CHAINE LATERALE DE TAXOL AU MOYEN D'UN CATALYSEUR TRIFONCTIONNEL HETEROGENE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2004056742A1

  公开（公告）日：2004-07-08

  The present invention relates to an improved process for the preparation of taxol side chain by synthesizing (2R,3S)-2,3-dihydroxy-3-phenylpropionate with greater than 99% enantioselectivity and devoid of osmium even in crude form in a single pot using a recyclable multifunctional catalysts, conversion of diol obtained without further crystallization into bromoacetate, reaction of bromoacetate with NaN3 in organic solvent followed by deacetylation with to obtain azido alcohol, benzoylation followed by hydrogenation of azido alcohol to obtain the (2R,3S)-(N-)-benzoyl-3-phenylisoserine methyl ester in 67% yield.

  本发明涉及一种改进的制备紫杉醇侧链的过程，通过使用可回收的多功能催化剂，在单一反应釜中合成大于99％对映选择性的（2R,3S）-2,3-二羟基-3-苯基丙酸酯，且即使在粗品中也不含锇，将获得的二醇转化为溴乙酸酯，然后在有机溶剂中与NaN3反应，脱乙酰化后得到偶氮醇，再进行苯甲酰化，随后氢化偶氮醇，以得到67％的（2R,3S）-（N-）苯甲酰-3-苯基异丝氨酸甲酯。
• [EN] MULTI-ARMED CATECHOL COMPOUND BLENDS<br/>[FR] MELANGES DE COMPOSES DE CATECHOL A BRANCHES MULTIPLES
  申请人：NERITES CORP

  公开号：WO2010037045A1

  公开（公告）日：2010-04-01

  The invention describes families of compounds that utilize multihydroxyl phenyl groups to provide adhesive properties. Selection of the multihydroxy phenyl group along with linkers or linking groups and the linkages between the linkers or linking groups with polyalkylene oxides, provides materials that can be engineered to afford controllable curing time, biodegradation and/or swelling.

  该发明描述了一系列利用多羟基苯基团提供粘合性能的化合物家族。选择多羟基苯基团以及连接剂或连接基团以及连接剂或连接基团与聚烷氧化物之间的连接，提供了可以被工程化的材料，以实现可控的固化时间、生物降解和/或肿胀性能。
• COMPOUNDS AND METHODS FOR FLUORESCENT LABELING
  申请人：Lukhtanov A. Eugeny

  公开号：US20050171340A1

  公开（公告）日：2005-08-04

  Dye reagents useful in labeling biological materials are provided along with methods for their use.

  提供了用于标记生物材料的染料试剂以及其使用方法。
• Compounds and methods for fluorescent labeling
  申请人：Lukhtanov A. Eugeny

  公开号：US20050277144A1

  公开（公告）日：2005-12-15

  Dye reagents useful in labeling biological materials are provided along with methods for their use.

  本发明提供了用于标记生物材料的染料试剂以及其使用方法。
• BIOADHESIVE CONSTRUCTS WITH POLYMER BLENDS
  申请人：Lee Bruce P.

  公开号：US20120003888A1

  公开（公告）日：2012-01-05

  The invention describes substrates, such as prosthetics, films, nonwovens, meshes, etc. that are treated with a bioadhesive polymer blend. The bioadhesive includes polymeric substances that have phenyl moieties with at least two hydroxyl groups. The bioadhesive blend constructs can be used to treat and repair, for example, hernias and damaged tendons.

  该发明涉及经过生物粘合聚合物混合物处理的基材，例如假体、薄膜、无纺布、网状物等。生物粘合剂包括具有至少两个羟基的苯基基团的聚合物物质。这些生物粘合混合物结构可用于治疗和修复疝气和受损的肌腱等。