2-[2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl]benzimidazole | 58553-87-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl]benzimidazole
• 英文别名: 1-<2-(5-Phenyl-1,2,4-oxadiazol-3-yl)ethyl>-benzimidazol；3-(2-Benzimidazol-1-yl)ethyl-5-phenyl-1,2,4-oxadiazole；3-[2-(benzimidazol-1-yl)ethyl]-5-phenyl-1,2,4-oxadiazole
• CAS: 58553-87-0
• 化学式: C₁₇H₁₄N₄O
• 分子量: 290.324
• InChiKey: VMGJSSTXBCZIKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  56.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  O-benzoyl-2-(benzimidazol-1-yl)propioamidoxime 反应 0.12h， 以58%的产率得到2-[2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl]benzimidazole
  参考文献：
  名称：

  Synthesis of 2-[2-(5-phenyl-1,2,4-oxadiazol-3-yl)-ethyl]benzimidazole and its x-ray analysis

  摘要：

  DOI：

  10.1007/s10593-006-0180-5

文献信息

• Antiparasitic agents. 6. Synthesis and anthelmintic activities of novel isothiocyanatophenyl-1,2,4-oxadiazoles
  作者：R. D. Haugwitz、A. J. Martinez、J. Venslavsky、R. G. Angel、B. V. Maurer、G. A. Jacobs、V. L. Narayanan、L. R. Cruthers、J. Szanto

  DOI：10.1021/jm00147a019

  日期：1985.9

  The syntheses and anthelmintic activities of 31 3- and 5-(isothiocyanatophenyl)-1,2,4-oxadiazoles are reported. In the primary anthelmintic screen, 3-(4-isothiocyanatophenyl)-1,2,4-oxadiazole (39) showed 100% nematocidal activity and 3-(2-furanyl)-5-(4-isothiocyanatophenyl)-1,2,4-oxadiazole (63), 3-(2-furanyl)-5-(2-chloro-4-isothiocyanatophenyl)-1,2,4-oxadiazole (64), and 3-(2-furanyl)-5-(4-chloro-3-isothiocyanatophenyl)-1,2,4-oxadiazole (66) showed 100% taeniacidal activity when administered orally to mice. The two most active members of this series, 39 and 63, were active against the gastrointestinal nematodes of sheep at 100 mg/kg. In addition, 39 was also found to be active against hookworms in dogs at a single, oral dose of 200 mg/kg.