SK5M6M | 1144040-04-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: SK5M6M
• 英文别名: 5,6-Dimethyl-5h-pyrido[4,3-b]indole；5,6-dimethylpyrido[4,3-b]indole
• CAS: 1144040-04-9
• 化学式: C₁₃H₁₂N₂
• mdl: MFCD18803675
• 分子量: 196.252
• InChiKey: BZNLPNBMHKRADM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.153
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  SK6M 、 碳酸二甲酯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 SK5M6M
  参考文献：
  名称：

  Polymethylated γ-Carbolines with Potent Anti-Bovine Viral Diarrhea Virus (BVDV) Activity

  摘要：

  Several anti-BVDV agents with a polymethylated gamma-carboline skeleton were synthesized, and their anti-BVDV activity was evaluated. The most potent antiviral agent, SK3M4M5M (20), was synthesized by Pd-catalyzed Buchwald-Hartwig amination reaction followed by annulation reaction as key steps. The structure-activity relationship was analyzed.

  DOI：

  10.3987/com-08-s(f)68

文献信息

• ELECTRON TRANSPORT MATERIALS FOR ELECTRONIC APPLICATIONS
  申请人：E I DU PONT DE NEMOURS AND COMPANY

  公开号：US20160343957A1

  公开（公告）日：2016-11-24

  There is provided a compound having Formula I In Formula I: E 1 -E 4 are CH, CD, or N, where one and only one of E 1 -E 4 is N; Ar 1 is an N-heterocycle or a deuterated N-heterocycle; Ar 2 is aryl, heteroaryl, diarylamino, or deuterated analogs thereof; R 1 and R 2 are the same or different and are D, alkyl, silyl, aryl, heteroaryl, deuterated alkyl, deuterated silyl, deuterated aryl, or deuterated heteroaryl; and a and al are the same or different and are integers from 0-3.

  提供了一种具有I式的化合物，在I式中：E1-E4为CH、CD或N，其中仅有E1-E4之一为N；Ar1为N-杂环或重氢化的N-杂环；Ar2为芳基、杂芳基、二芳基胺或其重氢化的类似物；R1和R2相同或不同，为D、烷基、硅烷基、芳基、杂芳基、重氢化的烷基、重氢化的硅烷基、重氢化的芳基或重氢化的杂芳基；a和al相同或不同，为0-3的整数。
• ANTI-VIRAL AGENT CONTAINING HETEROCYCLIC AROMATIC COMPOUND AS ACTIVE INGREDIENT
  申请人：Baba Masanori

  公开号：US20100256379A1

  公开（公告）日：2010-10-07

  The present invention relates to an anti-viral agent comprising a compound represented by the following formula (I): (wherein X represents CH, a nitrogen atom, an oxygen atom, or a sulfur atom; Y and Z are the same or different and each represents a nitrogen atom or C—R 8 , and at least one of them represents a nitrogen atom; R 1 to R 8 are the same or different and each represents a hydrogen atom, a linear C 1-10 -hydrocarbon group, a hydroxy group, or a substituted or unsubstituted benzyl group; and, when X represents an oxygen atom or a sulfur atom, R 5 is absent), or the following formula (II): (wherein X′ represents CH or a nitrogen atom; Y′ and Z′ are the same or different and each represents a nitrogen atom or N—R 9 , or C—R 8 and at least one of them represents a nitrogen atom or N—R 9 ; R 1 to R 4 and R 6 to R 8 are as defined above; R 9 represents a hydrogen atom, a linear C 1-10 -hydrocarbon group, a hydroxy group, or a substituted or unsubstituted benzyl group; and, the C ring has the maximum number of double bonds at the dotted line portion) or a pharmaceutically acceptable salt thereof.
• Polymethylated γ-Carbolines with Potent Anti-Bovine Viral Diarrhea Virus (BVDV) Activity
  作者：Hiroshi Aoyama、Kumiko Sako、Shinichi Sato、Masahiko Nakamura、Hiroyuki Miyachi、Yukinori Goto、Mika Okamoto、Masanori Baba、Yuichi Hashimoto

  DOI：10.3987/com-08-s(f)68

  日期：——

  Several anti-BVDV agents with a polymethylated gamma-carboline skeleton were synthesized, and their anti-BVDV activity was evaluated. The most potent antiviral agent, SK3M4M5M (20), was synthesized by Pd-catalyzed Buchwald-Hartwig amination reaction followed by annulation reaction as key steps. The structure-activity relationship was analyzed.