methyl 4-[4-[5,5,6,6,7,7,7-heptafluoro-1-(4-fluorophenylsulfonylamino)heptyl]phenyl]butyrate | 207987-08-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: methyl 4-[4-[5,5,6,6,7,7,7-heptafluoro-1-(4-fluorophenylsulfonylamino)heptyl]phenyl]butyrate
• 英文别名: Methyl 4-[4-[5,5,6,6,7,7,7-heptafluoro-1-[(4-fluorophenyl)sulfonylamino]heptyl]phenyl]butanoate
• CAS: 207987-08-4
• 化学式: C₂₄H₂₅F₈NO₄S
• 分子量: 575.52
• InChiKey: HPBMTMMLYTUAHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  38
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  13

文献信息

• BENZENESULFONAMIDE DERIVATIVES AND DRUGS CONTAINING THE SAME
  申请人：HOKURIKU SEIYAKU CO., LTD.

  公开号：EP0943606A1

  公开（公告）日：1999-09-22

  Novel benzenesulfonamide derivatives represented by the following general formula (I) are provided: wherein R1 represents hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxyl group, or nitro group; R2 represents a C4-C8 alkyl group which is substituted with one or more fluorine atoms; R3 represents hydrogen atom or a lower alkyl group; X represents sulfur atom or a group represented by CH=CH; and n represents an integer of from 2 to 4. Medicaments comprising said compound as an active ingredient can be used for preventive and/or therapeutic treatment of thrombosis, asthma, or allergic diseases.

  提供以下一般式（I）代表的新型苯磺酰胺衍生物：其中R1代表氢原子、卤素原子、低碳基、低碳氧基或硝基；R2代表一个或多个氟原子取代的C4-C8烷基；R3代表氢原子或低碳基；X代表硫原子或CH=CH代表的基团；n代表2到4之间的整数。包含该化合物作为活性成分的药物可用于预防和/或治疗血栓形成、哮喘或过敏性疾病。