| 1150209-40-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1150209-40-7
• 化学式: C₁₀H₂₀N₂O*ClH
• 分子量: 220.743
• InChiKey: ZHMLCZZHZIVVJX-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  (S)-3-(3-Cyano-phenyl)-2-(3-nitro-benzenesulfonylamino)-propionic acid 、 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.25h， 生成
  参考文献：
  名称：

  Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors

  摘要：

  A novel series of matriptase inhibitors based on previously identified tribasic 3-amidinophenylalanine derivatives was prepared. The C-terminal basic group was replaced by neutral residues to reduce the hydrophilicity of the inhibitors. The most potent compound 22 inhibits matriptase with a K-i value of 0.43 nM, but lacks selectivity towards factor Xa. By combination with neutral N-terminal sulfonyl residues several potent thrombin inhibitors were identified, which had reduced matriptase affinity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.047
• 作为产物：
  描述：

  C₁₅H₂₈N₂O₃ 在 盐酸 、 水 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors

  摘要：

  A novel series of matriptase inhibitors based on previously identified tribasic 3-amidinophenylalanine derivatives was prepared. The C-terminal basic group was replaced by neutral residues to reduce the hydrophilicity of the inhibitors. The most potent compound 22 inhibits matriptase with a K-i value of 0.43 nM, but lacks selectivity towards factor Xa. By combination with neutral N-terminal sulfonyl residues several potent thrombin inhibitors were identified, which had reduced matriptase affinity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.047